Constitutive upregulations of titin-based signalling proteins in KY deficient muscles

Jane Beatham, Katja Gehmlich, Peter F. M van der Ven, Jaakko Sarparanta, Debbie Williams, Peter Underhill, Christian Geier, Dieter O Furst, Bjarne Udd, Gonzalo Blanco

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in kylky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. (C) 2006 Elsevier B.V. All rights reserved.
    Originalspråkengelska
    TidskriftNeuromuscular Disorders
    Volym16
    Utgåva7
    Sidor (från-till)437-445
    Antal sidor9
    ISSN0960-8966
    DOI
    StatusPublicerad - 2006
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Citera det här

    Beatham, J., Gehmlich, K., van der Ven, P. F. M., Sarparanta, J., Williams, D., Underhill, P., ... Blanco, G. (2006). Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. Neuromuscular Disorders, 16(7), 437-445. https://doi.org/10.1016/j.nmd.2006.05.013
    Beatham, Jane ; Gehmlich, Katja ; van der Ven, Peter F. M ; Sarparanta, Jaakko ; Williams, Debbie ; Underhill, Peter ; Geier, Christian ; Furst, Dieter O ; Udd, Bjarne ; Blanco, Gonzalo. / Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. I: Neuromuscular Disorders. 2006 ; Vol. 16, Nr. 7. s. 437-445.
    @article{5b284dbea1bf4fcabcec41e7c1050f11,
    title = "Constitutive upregulations of titin-based signalling proteins in KY deficient muscles",
    abstract = "An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in kylky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. (C) 2006 Elsevier B.V. All rights reserved.",
    author = "Jane Beatham and Katja Gehmlich and {van der Ven}, {Peter F. M} and Jaakko Sarparanta and Debbie Williams and Peter Underhill and Christian Geier and Furst, {Dieter O} and Bjarne Udd and Gonzalo Blanco",
    year = "2006",
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    language = "English",
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    journal = "Neuromuscular Disorders",
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    Beatham, J, Gehmlich, K, van der Ven, PFM, Sarparanta, J, Williams, D, Underhill, P, Geier, C, Furst, DO, Udd, B & Blanco, G 2006, 'Constitutive upregulations of titin-based signalling proteins in KY deficient muscles', Neuromuscular Disorders, vol. 16, nr. 7, s. 437-445. https://doi.org/10.1016/j.nmd.2006.05.013

    Constitutive upregulations of titin-based signalling proteins in KY deficient muscles. / Beatham, Jane; Gehmlich, Katja; van der Ven, Peter F. M; Sarparanta, Jaakko; Williams, Debbie; Underhill, Peter; Geier, Christian; Furst, Dieter O; Udd, Bjarne; Blanco, Gonzalo.

    I: Neuromuscular Disorders, Vol. 16, Nr. 7, 2006, s. 437-445.

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    TY - JOUR

    T1 - Constitutive upregulations of titin-based signalling proteins in KY deficient muscles

    AU - Beatham, Jane

    AU - Gehmlich, Katja

    AU - van der Ven, Peter F. M

    AU - Sarparanta, Jaakko

    AU - Williams, Debbie

    AU - Underhill, Peter

    AU - Geier, Christian

    AU - Furst, Dieter O

    AU - Udd, Bjarne

    AU - Blanco, Gonzalo

    PY - 2006

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    N2 - An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in kylky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. (C) 2006 Elsevier B.V. All rights reserved.

    AB - An increase in the expression of stretch/stress response elements in fast and slow muscles has been previously described in a transcriptional profiling of KY deficient muscles. Here, we have characterized the induction of this titin-based family of signalling proteins in ky/ky muscles at the protein level. Changes in expression of MLP, MARP2 and Xin have been related to the onset of dystrophic and adaptive changes that operate in kylky muscles. Our results indicate that induction of this set of genes is an early consequence of the interference caused by the absence of the KY protein. A search of muscle profiles of mouse models revealed such molecular hallmark only in muscles subjected to a single bout of eccentric contractions and specific titin mutants. Based on the role of this family as titin-based stress response molecules, it is suggested that titin structural/signalling instability is common to ky and titin mouse mutants and eccentric contractions. (C) 2006 Elsevier B.V. All rights reserved.

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