Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter)

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Sammanfattning

Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.
Originalspråkengelska
Titel på gästpublikationIntegrin Targeting Systems for Tumor Diagnosis and Therapy
RedaktörerEleonora Patsenker
Antal sidor15
UtgivningsortNew York
FörlagSpringer Science+Business Media
Utgivningsdatum2018
Sidor35-49
ISBN (tryckt)978-1-4939-7443-6
ISBN (elektroniskt)978-1-4939-7445-0
DOI
StatusPublicerad - 2018
MoE-publikationstypA3 Del av bok eller annan forskningsbok

Publikationsserier

Namn Methods in Pharmacology and Toxicology
ISSN (tryckt)1557-2153
ISSN (elektroniskt)1940-6053

Vetenskapsgrenar

  • 317 Farmaci

Citera det här

Wang, C-F., & Santos, H. A. (2018). Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). I E. Patsenker (Red.), Integrin Targeting Systems for Tumor Diagnosis and Therapy (s. 35-49). ( Methods in Pharmacology and Toxicology). New York: Springer Science+Business Media. https://doi.org/10.1007/7653_2015_44
Wang, Chang-Fang ; Santos, Hélder A. / Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). Integrin Targeting Systems for Tumor Diagnosis and Therapy. redaktör / Eleonora Patsenker. New York : Springer Science+Business Media, 2018. s. 35-49 ( Methods in Pharmacology and Toxicology).
@inbook{f7b9347494c04227879c9b10797028b9,
title = "Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter)",
abstract = "Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.",
keywords = "317 Pharmacy, Multiple organ diseases, Structural analysis, Biomarkers, Drug delivery, Cancer research, Integrin imaging",
author = "Chang-Fang Wang and Santos, {H{\'e}lder A.}",
year = "2018",
doi = "10.1007/7653_2015_44",
language = "English",
isbn = "978-1-4939-7443-6",
series = "Methods in Pharmacology and Toxicology",
publisher = "Springer Science+Business Media",
pages = "35--49",
editor = "Eleonora Patsenker",
booktitle = "Integrin Targeting Systems for Tumor Diagnosis and Therapy",
address = "International",

}

Wang, C-F & Santos, HA 2018, Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). i E Patsenker (red.), Integrin Targeting Systems for Tumor Diagnosis and Therapy. Methods in Pharmacology and Toxicology, Springer Science+Business Media, New York, s. 35-49. https://doi.org/10.1007/7653_2015_44

Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). / Wang, Chang-Fang; Santos, Hélder A.

Integrin Targeting Systems for Tumor Diagnosis and Therapy. red. / Eleonora Patsenker. New York : Springer Science+Business Media, 2018. s. 35-49 ( Methods in Pharmacology and Toxicology).

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

TY - CHAP

T1 - Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter)

AU - Wang, Chang-Fang

AU - Santos, Hélder A.

PY - 2018

Y1 - 2018

N2 - Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.

AB - Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.

KW - 317 Pharmacy

KW - Multiple organ diseases

KW - Structural analysis

KW - Biomarkers

KW - Drug delivery

KW - Cancer research

KW - Integrin imaging

U2 - 10.1007/7653_2015_44

DO - 10.1007/7653_2015_44

M3 - Chapter

SN - 978-1-4939-7443-6

T3 - Methods in Pharmacology and Toxicology

SP - 35

EP - 49

BT - Integrin Targeting Systems for Tumor Diagnosis and Therapy

A2 - Patsenker, Eleonora

PB - Springer Science+Business Media

CY - New York

ER -

Wang C-F, Santos HA. Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). I Patsenker E, redaktör, Integrin Targeting Systems for Tumor Diagnosis and Therapy. New York: Springer Science+Business Media. 2018. s. 35-49. ( Methods in Pharmacology and Toxicology). https://doi.org/10.1007/7653_2015_44