Cytokinin signaling and its inhibitor AHP6 regulate cell fate during vascular development

Ari Pekka Mähönen, Anthony Bishopp, Masayuki Higuchi, Kaisa M Nieminen, Kaori Kinoshita, Kirsi Törmäkangas, Yoshihisa Ikeda, Atsuhiro Oka, Tatsuo Kakimoto, Yrjö Helariutta

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    The cell lineages that form the transporting tissues (xylem and phloem) and the intervening pluripotent procambial tissue originate from stem cells near the root tip. We demonstrate that in Arabidopsis, cytokinin phytohormones negatively regulate protoxylem specification. AHP6, an inhibitory pseudophosphotransfer protein, counteracts cytokinin signaling, allowing protoxylem formation. Conversely, cytokinin signaling negatively regulates the spatial domain of AHP6 expression. Thus, by controlling the identity of cell lineages, the reciprocal interaction of cytokinin signaling and its spatially specific modulator regulates proliferation and differentiation of cell lineages during vascular development, demonstrating a previously unrecognized regulatory circuit underlying meristem organization.
    Originalspråkengelska
    TidskriftScience
    Volym311
    Utgåva5757
    Sidor (från-till)94-98
    Antal sidor5
    ISSN0036-8075
    DOI
    StatusPublicerad - 2006
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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