Deciphering the role of specific tear film lipids in dry eye syndrome (DES)

Tuomo Viitaja, Helena Bland, Jan-Erik Raitanen, Jukka Moilanen, Riku O Paananen, Filip Ekholm

Forskningsoutput: KonferensbidragPosterPeer review


Dry eye syndrome (DES) is a disease of the ocular surface characterized by tear film instability, hyperosmolarityand ocular surface damage. DES has a prevalence of 10–30% in the adult population and constitutes a heavy economic burden with estimated annual direct and indirect costs of $55 billion in the US alone. One of the main causes of DES is thought to be an alteration in the composition of the outermost layer of the tear film, the tear film lipid layer (TFLL), resulting in increased evaporation of water from the tear film and subsequent drying of the ocular surface. It was previously suggested that the specific TFLL-lipids O-acyl-ω-hydroxy-fatty acids (OAHFAs) and diesters (DiEs) may play a role in development of DES. However, the specific connection to DES was largely unknown due to the lack of information on their biophysical properties which would shed light on their function in the TFLL. In order to obtain insights on the role of these lipids in the TFLL, we synthesized a library of structural analogues and studied their surface behaviour at the air-water interface and the evaporation resistance of the films formed. Our results showed that only one of the previously suggested lipid classes have the desired anti-evaporative properties which are of importance in a properly functioning TFLL. At the conference, the results of our recent studies on the topic will be presented
Antal sidor1
StatusPublicerad - 1 sep 2019
MoE-publikationstypEj behörig
EvenemangEFMC-ASMC'19: EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry - Athens, Grekland
Varaktighet: 1 sep 20195 sep 2019




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