Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

Sakari Vanharanta, Noel C Wortham, Cordelia Langford, Mona El-Bahrawy, Zephne van der Spuy, Jari Sjöberg, Rainer Lehtonen, Auli Karhu, Ian P. M Tomlinson, Lauri A Aaltonen

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the region for mutations. We have refined the minimum deleted region at 7q22.3-q31 to 2.79 Mbp and didentified a second region of deletion at 7q34. However, we identified no pathogenic coding variation. (c) 2007 Wiley-Liss, Inc.
    Originalspråkengelska
    TidskriftGenes, Chromosomes & Cancer
    Volym46
    Utgåva5
    Sidor (från-till)451-458
    Antal sidor8
    ISSN1045-2257
    DOI
    StatusPublicerad - 2007
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Vetenskapsgrenar

    • 311 Basmedicin

    Citera det här

    Vanharanta, Sakari ; Wortham, Noel C ; Langford, Cordelia ; El-Bahrawy, Mona ; van der Spuy, Zephne ; Sjöberg, Jari ; Lehtonen, Rainer ; Karhu, Auli ; Tomlinson, Ian P. M ; Aaltonen, Lauri A. / Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region. I: Genes, Chromosomes & Cancer. 2007 ; Vol. 46, Nr. 5. s. 451-458.
    @article{3607437887c742b88f5e0abaa052cd1c,
    title = "Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region",
    abstract = "Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the region for mutations. We have refined the minimum deleted region at 7q22.3-q31 to 2.79 Mbp and didentified a second region of deletion at 7q34. However, we identified no pathogenic coding variation. (c) 2007 Wiley-Liss, Inc.",
    keywords = "311 Basic medicine",
    author = "Sakari Vanharanta and Wortham, {Noel C} and Cordelia Langford and Mona El-Bahrawy and {van der Spuy}, Zephne and Jari Sj{\"o}berg and Rainer Lehtonen and Auli Karhu and Tomlinson, {Ian P. M} and Aaltonen, {Lauri A}",
    year = "2007",
    doi = "10.1002/gcc.20427",
    language = "English",
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    pages = "451--458",
    journal = "Genes, Chromosomes & Cancer",
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    publisher = "Wiley",
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    }

    Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region. / Vanharanta, Sakari; Wortham, Noel C; Langford, Cordelia; El-Bahrawy, Mona; van der Spuy, Zephne; Sjöberg, Jari; Lehtonen, Rainer; Karhu, Auli; Tomlinson, Ian P. M; Aaltonen, Lauri A.

    I: Genes, Chromosomes & Cancer, Vol. 46, Nr. 5, 2007, s. 451-458.

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    TY - JOUR

    T1 - Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

    AU - Vanharanta, Sakari

    AU - Wortham, Noel C

    AU - Langford, Cordelia

    AU - El-Bahrawy, Mona

    AU - van der Spuy, Zephne

    AU - Sjöberg, Jari

    AU - Lehtonen, Rainer

    AU - Karhu, Auli

    AU - Tomlinson, Ian P. M

    AU - Aaltonen, Lauri A

    PY - 2007

    Y1 - 2007

    N2 - Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the region for mutations. We have refined the minimum deleted region at 7q22.3-q31 to 2.79 Mbp and didentified a second region of deletion at 7q34. However, we identified no pathogenic coding variation. (c) 2007 Wiley-Liss, Inc.

    AB - Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region. Previous LOH and CGH studies have refined this region to 7q22.3-q31, although the target gene has not been identified. Here, we have used tiling-path resolution microarray CGH to further refine the region and to identify homozygous deletions in fibroids. Furthermore, we have screened all manually annotated genes in the region for mutations. We have refined the minimum deleted region at 7q22.3-q31 to 2.79 Mbp and didentified a second region of deletion at 7q34. However, we identified no pathogenic coding variation. (c) 2007 Wiley-Liss, Inc.

    KW - 311 Basic medicine

    U2 - 10.1002/gcc.20427

    DO - 10.1002/gcc.20427

    M3 - Article

    VL - 46

    SP - 451

    EP - 458

    JO - Genes, Chromosomes & Cancer

    JF - Genes, Chromosomes & Cancer

    SN - 1045-2257

    IS - 5

    ER -