Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Shishir M. Pant, Amanda Mukonoweshuro, Bimbisar Desai, Manoj K. Ramjee, Christopher N. Selway, Gary J. Tarver, Adrian G. Wright, Kristian Birchall, Timothy M. Chapman, Topi A. Tervonen, Juha Klefström

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Originalspråkengelska
TidskriftJournal of Medicinal Chemistry
Volym61
Utgåva10
Sidor (från-till)4335-4347
Antal sidor13
ISSN0022-2623
DOI
StatusPublicerad - 24 maj 2018
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3111 Biomedicinska vetenskaper

Citera det här

Pant, Shishir M. ; Mukonoweshuro, Amanda ; Desai, Bimbisar ; Ramjee, Manoj K. ; Selway, Christopher N. ; Tarver, Gary J. ; Wright, Adrian G. ; Birchall, Kristian ; Chapman, Timothy M. ; Tervonen, Topi A. ; Klefström, Juha. / Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. I: Journal of Medicinal Chemistry. 2018 ; Vol. 61, Nr. 10. s. 4335-4347.
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keywords = "HEPATOCYTE GROWTH-FACTOR, PROTEASE ACTIVITY, PROSTATE-CANCER, KINASE INHIBITORS, OVARIAN-CANCER, TRYPSIN, METASTASIS, DISCOVERY, THROMBIN, MET, 3111 Biomedicine",
author = "Pant, {Shishir M.} and Amanda Mukonoweshuro and Bimbisar Desai and Ramjee, {Manoj K.} and Selway, {Christopher N.} and Tarver, {Gary J.} and Wright, {Adrian G.} and Kristian Birchall and Chapman, {Timothy M.} and Tervonen, {Topi A.} and Juha Klefstr{\"o}m",
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Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. / Pant, Shishir M.; Mukonoweshuro, Amanda; Desai, Bimbisar; Ramjee, Manoj K.; Selway, Christopher N.; Tarver, Gary J.; Wright, Adrian G.; Birchall, Kristian; Chapman, Timothy M.; Tervonen, Topi A.; Klefström, Juha.

I: Journal of Medicinal Chemistry, Vol. 61, Nr. 10, 24.05.2018, s. 4335-4347.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

AU - Pant, Shishir M.

AU - Mukonoweshuro, Amanda

AU - Desai, Bimbisar

AU - Ramjee, Manoj K.

AU - Selway, Christopher N.

AU - Tarver, Gary J.

AU - Wright, Adrian G.

AU - Birchall, Kristian

AU - Chapman, Timothy M.

AU - Tervonen, Topi A.

AU - Klefström, Juha

PY - 2018/5/24

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KW - HEPATOCYTE GROWTH-FACTOR

KW - PROTEASE ACTIVITY

KW - PROSTATE-CANCER

KW - KINASE INHIBITORS

KW - OVARIAN-CANCER

KW - TRYPSIN

KW - METASTASIS

KW - DISCOVERY

KW - THROMBIN

KW - MET

KW - 3111 Biomedicine

U2 - 10.1021/acs.jmedchem.7601698

DO - 10.1021/acs.jmedchem.7601698

M3 - Article

VL - 61

SP - 4335

EP - 4347

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 10

ER -