Developmental origins of mental health

human observational studies of preterm birth, antenatal synthetic glucocorticoid exposure, and maternal depressive symptoms during pregnancy

Elina Wolford

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

Sammanfattning

Mental disorders are a considerable factor in the global burden of disease, with population growth and aging increasing the prevalence of the disorders. While interventions and treatment to ameliorate the burden of mental disorders is important, another critical goal is to find possible risk factors for optimal mental health. According to the Developmental Origins of Health and Disease hypothesis, environmental factors during pregnancy and fetal life may have adverse programming effects on offspring mental health. However, observational human studies on the long term effects of an adverse fetal life are still needed. The aim of this work was to study the developmental origins of mental health focusing on three important risk factors: preterm birth (birth before 37 weeks of gestation), exposure to antenatal synthetic glucocorticoids (sGC), and maternal depressive symptoms during pregnancy. Specifically, to study the long term effects of preterm birth at very low birth weight (VLBW; birth weight
Originalspråkengelska
Handledare
  • Räikkönen, Katri, Handledare
  • Lahti, Marius, Handledare
Tilldelningsdatum12 dec 2018
UtgivningsortHelsinki
Förlag
Tryckta ISBN978-951-51-4738-7
Elektroniska ISBN978-951-51-4739-4
StatusPublicerad - 2018
MoE-publikationstypG5 Doktorsavhandling (artikel)

Vetenskapsgrenar

  • 515 Psykologi

Citera det här

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title = "Developmental origins of mental health: human observational studies of preterm birth, antenatal synthetic glucocorticoid exposure, and maternal depressive symptoms during pregnancy",
abstract = "Mental disorders are a considerable factor in the global burden of disease, with population growth and aging increasing the prevalence of the disorders. While interventions and treatment to ameliorate the burden of mental disorders is important, another critical goal is to find possible risk factors for optimal mental health. According to the Developmental Origins of Health and Disease hypothesis, environmental factors during pregnancy and fetal life may have adverse programming effects on offspring mental health. However, observational human studies on the long term effects of an adverse fetal life are still needed. The aim of this work was to study the developmental origins of mental health focusing on three important risk factors: preterm birth (birth before 37 weeks of gestation), exposure to antenatal synthetic glucocorticoids (sGC), and maternal depressive symptoms during pregnancy. Specifically, to study the long term effects of preterm birth at very low birth weight (VLBW; birth weight",
keywords = "Cognition Disorders, Betamethasone, Prenatal Exposure Delayed Effects, Infant, Low Birth Weight, Infant, Very Low Birth Weight, Pregnant Women, 515 Psychology",
author = "Elina Wolford",
note = "M1 - 103 s. + liitteet",
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Developmental origins of mental health : human observational studies of preterm birth, antenatal synthetic glucocorticoid exposure, and maternal depressive symptoms during pregnancy. / Wolford, Elina.

Helsinki : [E. Wolford], 2018. 103 s.

Forskningsoutput: AvhandlingDoktorsavhandlingSamling av artiklar

TY - THES

T1 - Developmental origins of mental health

T2 - human observational studies of preterm birth, antenatal synthetic glucocorticoid exposure, and maternal depressive symptoms during pregnancy

AU - Wolford, Elina

N1 - M1 - 103 s. + liitteet

PY - 2018

Y1 - 2018

N2 - Mental disorders are a considerable factor in the global burden of disease, with population growth and aging increasing the prevalence of the disorders. While interventions and treatment to ameliorate the burden of mental disorders is important, another critical goal is to find possible risk factors for optimal mental health. According to the Developmental Origins of Health and Disease hypothesis, environmental factors during pregnancy and fetal life may have adverse programming effects on offspring mental health. However, observational human studies on the long term effects of an adverse fetal life are still needed. The aim of this work was to study the developmental origins of mental health focusing on three important risk factors: preterm birth (birth before 37 weeks of gestation), exposure to antenatal synthetic glucocorticoids (sGC), and maternal depressive symptoms during pregnancy. Specifically, to study the long term effects of preterm birth at very low birth weight (VLBW; birth weight

AB - Mental disorders are a considerable factor in the global burden of disease, with population growth and aging increasing the prevalence of the disorders. While interventions and treatment to ameliorate the burden of mental disorders is important, another critical goal is to find possible risk factors for optimal mental health. According to the Developmental Origins of Health and Disease hypothesis, environmental factors during pregnancy and fetal life may have adverse programming effects on offspring mental health. However, observational human studies on the long term effects of an adverse fetal life are still needed. The aim of this work was to study the developmental origins of mental health focusing on three important risk factors: preterm birth (birth before 37 weeks of gestation), exposure to antenatal synthetic glucocorticoids (sGC), and maternal depressive symptoms during pregnancy. Specifically, to study the long term effects of preterm birth at very low birth weight (VLBW; birth weight

KW - Cognition Disorders

KW - Betamethasone

KW - Prenatal Exposure Delayed Effects

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KW - Infant, Very Low Birth Weight

KW - Pregnant Women

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