Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation

Roland Kun, Ana Carolina S. Gomes, Sari Kristiina Hilden, Sonia Salazar Cerezo, Miia Riitta Mäkelä, Ronald de Vries

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

Fungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. In this review, the main approaches for strain engineering of filamentous fungi in the field of plant biomass degradation will be discussed, including recent and not yet implemented methods, such as CRISPR/Cas9 genome editing and adaptive evolution.

Originalspråkengelska
Artikelnummer107361
TidskriftBiotechnology Advances
Volym37
Utgåva6-7
Antal sidor16
ISSN0734-9750
DOI
StatusPublicerad - 1 nov 2019
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi

Citera det här

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title = "Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation",
abstract = "Fungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. In this review, the main approaches for strain engineering of filamentous fungi in the field of plant biomass degradation will be discussed, including recent and not yet implemented methods, such as CRISPR/Cas9 genome editing and adaptive evolution.",
keywords = "1182 Biochemistry, cell and molecular biology, UV mutagenesis, Chemical mutagenesis, Adaptive evolution, Genetic engineering, Genome editing, Epigenetics, Omits, SOLID-STATE FERMENTATION, POLYSACCHARIDE-DEGRADING ENZYMES, MANNAN UTILIZATION SYSTEM, TRICHODERMA-REESEI, ASPERGILLUS-NIGER, SACCHAROMYCES-CEREVISIAE, CELLULASE PRODUCTION, TRANSCRIPTIONAL ACTIVATOR, HYPER-PRODUCTION, GENE-EXPRESSION",
author = "Roland Kun and Gomes, {Ana Carolina S.} and Hilden, {Sari Kristiina} and {Salazar Cerezo}, Sonia and M{\"a}kel{\"a}, {Miia Riitta} and {de Vries}, Ronald",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.biotechadv.2019.02.017",
language = "English",
volume = "37",
journal = "Biotechnology Advances",
issn = "0734-9750",
publisher = "Elsevier Scientific Publ. Co",
number = "6-7",

}

Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation. / Kun, Roland; Gomes, Ana Carolina S. ; Hilden, Sari Kristiina; Salazar Cerezo, Sonia ; Mäkelä, Miia Riitta; de Vries, Ronald.

I: Biotechnology Advances, Vol. 37, Nr. 6-7, 107361, 01.11.2019.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

TY - JOUR

T1 - Developments and opportunities in fungal strain engineering for the production of novel enzymes and enzyme cocktails for plant biomass degradation

AU - Kun, Roland

AU - Gomes, Ana Carolina S.

AU - Hilden, Sari Kristiina

AU - Salazar Cerezo, Sonia

AU - Mäkelä, Miia Riitta

AU - de Vries, Ronald

PY - 2019/11/1

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AB - Fungal strain engineering is commonly used in many areas of biotechnology, including the production of plant biomass degrading enzymes. Its aim varies from the production of specific enzymes to overall increased enzyme production levels and modification of the composition of the enzyme set that is produced by the fungus. Strain engineering involves a diverse range of methodologies, including classical mutagenesis, genetic engineering and genome editing. In this review, the main approaches for strain engineering of filamentous fungi in the field of plant biomass degradation will be discussed, including recent and not yet implemented methods, such as CRISPR/Cas9 genome editing and adaptive evolution.

KW - 1182 Biochemistry, cell and molecular biology

KW - UV mutagenesis

KW - Chemical mutagenesis

KW - Adaptive evolution

KW - Genetic engineering

KW - Genome editing

KW - Epigenetics

KW - Omits

KW - SOLID-STATE FERMENTATION

KW - POLYSACCHARIDE-DEGRADING ENZYMES

KW - MANNAN UTILIZATION SYSTEM

KW - TRICHODERMA-REESEI

KW - ASPERGILLUS-NIGER

KW - SACCHAROMYCES-CEREVISIAE

KW - CELLULASE PRODUCTION

KW - TRANSCRIPTIONAL ACTIVATOR

KW - HYPER-PRODUCTION

KW - GENE-EXPRESSION

U2 - 10.1016/j.biotechadv.2019.02.017

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