Diatomite Nanoparticles as Potential Drug Delivery Systems

M. Terracciano, A. Lamberti, H. A. Santos, N.M. Martucci, Mohammad-Ali Shahbazi, A. Correia, I. Ruggiero, I. Rendina, L. De Stefano, I. Rea

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKonferensbidragVetenskapligPeer review

Sammanfattning

Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this work, the properties of diatomite nanoparticles as potential system for the drug delivery in cancer cells are exploited. A purification procedure, based on treatments in strong acid solutions, is used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. Morphology and composition of diatomite nanoparticles are investigated by SEM equipped by energy dispersive X-ray spectroscopy, FTIR analysis and photoluminescence measurements. Nanometric porous particles (average size lower than 350 nm) are obtained by mechanical crushing, sonication, and filtering of micrometric frustules. Moreover, diatomite nanoparticles are modified by a proper biochemical functionalization of surface, in order to improve their physicochemical properties and biocompatibility for in vitro studies.
Originalspråkengelska
Titel på gästpublikation3rd International Conference BioPhotonics 2015
Antal sidor3
FörlagIEEE
Utgivningsdatum30 okt 2015
Sidor1-3
ISBN (tryckt)978-1-4673-7925-0
ISBN (elektroniskt)978-1-4673-7926-7
DOI
StatusPublicerad - 30 okt 2015
MoE-publikationstypA4 Artikel i en konferenspublikation
EvenemangInternational Conference BioPhotonics - Florence, Italien
Varaktighet: 20 maj 201522 maj 2015
Konferensnummer: 3rd

Vetenskapsgrenar

  • 317 Farmaci

Citera det här

Terracciano, M., Lamberti, A., A. Santos, H., Martucci, N. M., Shahbazi, M-A., Correia, A., ... Rea, I. (2015). Diatomite Nanoparticles as Potential Drug Delivery Systems. I 3rd International Conference BioPhotonics 2015 (s. 1-3). IEEE. https://doi.org/10.1109/BioPhotonics.2015.7304032
Terracciano, M. ; Lamberti, A. ; A. Santos, H. ; Martucci, N.M. ; Shahbazi, Mohammad-Ali ; Correia, A. ; Ruggiero, I. ; Rendina, I. ; De Stefano, L. ; Rea, I. / Diatomite Nanoparticles as Potential Drug Delivery Systems. 3rd International Conference BioPhotonics 2015. IEEE, 2015. s. 1-3
@inproceedings{217074fe5dd84106844832479c6279d0,
title = "Diatomite Nanoparticles as Potential Drug Delivery Systems",
abstract = "Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this work, the properties of diatomite nanoparticles as potential system for the drug delivery in cancer cells are exploited. A purification procedure, based on treatments in strong acid solutions, is used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. Morphology and composition of diatomite nanoparticles are investigated by SEM equipped by energy dispersive X-ray spectroscopy, FTIR analysis and photoluminescence measurements. Nanometric porous particles (average size lower than 350 nm) are obtained by mechanical crushing, sonication, and filtering of micrometric frustules. Moreover, diatomite nanoparticles are modified by a proper biochemical functionalization of surface, in order to improve their physicochemical properties and biocompatibility for in vitro studies.",
keywords = "317 Pharmacy",
author = "M. Terracciano and A. Lamberti and {A. Santos}, H. and N.M. Martucci and Mohammad-Ali Shahbazi and A. Correia and I. Ruggiero and I. Rendina and {De Stefano}, L. and I. Rea",
note = "Volume: Proceeding volume:",
year = "2015",
month = "10",
day = "30",
doi = "10.1109/BioPhotonics.2015.7304032",
language = "English",
isbn = "978-1-4673-7925-0",
pages = "1--3",
booktitle = "3rd International Conference BioPhotonics 2015",
publisher = "IEEE",
address = "International",

}

Terracciano, M, Lamberti, A, A. Santos, H, Martucci, NM, Shahbazi, M-A, Correia, A, Ruggiero, I, Rendina, I, De Stefano, L & Rea, I 2015, Diatomite Nanoparticles as Potential Drug Delivery Systems. i 3rd International Conference BioPhotonics 2015. IEEE, s. 1-3, International Conference BioPhotonics , Florence, Italien, 20/05/2015. https://doi.org/10.1109/BioPhotonics.2015.7304032

Diatomite Nanoparticles as Potential Drug Delivery Systems. / Terracciano, M.; Lamberti, A.; A. Santos, H.; Martucci, N.M.; Shahbazi, Mohammad-Ali; Correia, A.; Ruggiero, I.; Rendina, I.; De Stefano, L. ; Rea, I.

3rd International Conference BioPhotonics 2015. IEEE, 2015. s. 1-3.

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKonferensbidragVetenskapligPeer review

TY - GEN

T1 - Diatomite Nanoparticles as Potential Drug Delivery Systems

AU - Terracciano, M.

AU - Lamberti, A.

AU - A. Santos, H.

AU - Martucci, N.M.

AU - Shahbazi, Mohammad-Ali

AU - Correia, A.

AU - Ruggiero, I.

AU - Rendina, I.

AU - De Stefano, L.

AU - Rea, I.

N1 - Volume: Proceeding volume:

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this work, the properties of diatomite nanoparticles as potential system for the drug delivery in cancer cells are exploited. A purification procedure, based on treatments in strong acid solutions, is used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. Morphology and composition of diatomite nanoparticles are investigated by SEM equipped by energy dispersive X-ray spectroscopy, FTIR analysis and photoluminescence measurements. Nanometric porous particles (average size lower than 350 nm) are obtained by mechanical crushing, sonication, and filtering of micrometric frustules. Moreover, diatomite nanoparticles are modified by a proper biochemical functionalization of surface, in order to improve their physicochemical properties and biocompatibility for in vitro studies.

AB - Diatomite is a natural fossil material of sedimentary origin, constituted by fragments of diatom siliceous skeletons. In this work, the properties of diatomite nanoparticles as potential system for the drug delivery in cancer cells are exploited. A purification procedure, based on treatments in strong acid solutions, is used to remove inorganic and organic impurities from diatomite and to make them a safe material for medical applications. Morphology and composition of diatomite nanoparticles are investigated by SEM equipped by energy dispersive X-ray spectroscopy, FTIR analysis and photoluminescence measurements. Nanometric porous particles (average size lower than 350 nm) are obtained by mechanical crushing, sonication, and filtering of micrometric frustules. Moreover, diatomite nanoparticles are modified by a proper biochemical functionalization of surface, in order to improve their physicochemical properties and biocompatibility for in vitro studies.

KW - 317 Pharmacy

UR - http://dx.doi.org/10.1109/BioPhotonics.2015.7304032

U2 - 10.1109/BioPhotonics.2015.7304032

DO - 10.1109/BioPhotonics.2015.7304032

M3 - Conference contribution

SN - 978-1-4673-7925-0

SP - 1

EP - 3

BT - 3rd International Conference BioPhotonics 2015

PB - IEEE

ER -

Terracciano M, Lamberti A, A. Santos H, Martucci NM, Shahbazi M-A, Correia A et al. Diatomite Nanoparticles as Potential Drug Delivery Systems. I 3rd International Conference BioPhotonics 2015. IEEE. 2015. s. 1-3 https://doi.org/10.1109/BioPhotonics.2015.7304032