Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

Kevin D. Cashman, Christian Ritz, Folasade Abiola Adebayo, Kirsten G. Dowling, Suvi Tuulikki Itkonen, Taina Öhman, Essi Johanna Skaffari, Elisa Saarnio, Mairead Kiely, Christel Johanna Emilia Lamberg-Allardt

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Context Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities.

Objective To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations >= 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude.

Methods We used data from a 5-month, winter-based, vitamin D-3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21-64-year old, living in Southern Finland (60 degrees N), to model the vitamin D intake-serum 25(OH)D dose-response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L.

Results Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D >= 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 mu g/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds.

Conclusion The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

Originalspråkengelska
TidskriftEuropean Journal of Nutrition
Volym58
Utgåva6
Sidor (från-till)2281–2291
Antal sidor11
ISSN1436-6207
DOI
StatusPublicerad - sep 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 416 Livsmedelsvetenskap
  • 3143 Nutrition

Citera det här

@article{3f5d23c8c4f04a32a4f8fccaf2b9b71c,
title = "Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude",
abstract = "Context Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities.Objective To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations >= 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude.Methods We used data from a 5-month, winter-based, vitamin D-3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21-64-year old, living in Southern Finland (60 degrees N), to model the vitamin D intake-serum 25(OH)D dose-response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5{\%} (as well as 50, 90, and 95{\%}) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L.Results Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D >= 30 nmol/L in 97.5{\%} of Caucasian and Somali women was 8 and 18 mu g/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds.Conclusion The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.",
keywords = "416 Food Science, 3143 Nutrition, Vitamin D requirements, Ethnic-related differences, Dietary reference values, RCT, STANDARDIZATION PROGRAM PROTOCOLS, 25-HYDROXYVITAMIN D DATA, D SUPPLEMENTATION, D DEFICIENCY, DOSE-RESPONSE, WHITE, POPULATION, IMMIGRANT, PREVENTION, AMERICANS",
author = "Cashman, {Kevin D.} and Christian Ritz and Adebayo, {Folasade Abiola} and Dowling, {Kirsten G.} and Itkonen, {Suvi Tuulikki} and Taina {\"O}hman and Skaffari, {Essi Johanna} and Elisa Saarnio and Mairead Kiely and Lamberg-Allardt, {Christel Johanna Emilia}",
year = "2019",
month = "9",
doi = "10.1007/s00394-018-1775-1",
language = "English",
volume = "58",
pages = "2281–2291",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Heidelberg",
number = "6",

}

Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude. / Cashman, Kevin D.; Ritz, Christian; Adebayo, Folasade Abiola; Dowling, Kirsten G.; Itkonen, Suvi Tuulikki; Öhman, Taina; Skaffari, Essi Johanna; Saarnio, Elisa; Kiely, Mairead; Lamberg-Allardt, Christel Johanna Emilia.

I: European Journal of Nutrition, Vol. 58, Nr. 6, 09.2019, s. 2281–2291.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

AU - Cashman, Kevin D.

AU - Ritz, Christian

AU - Adebayo, Folasade Abiola

AU - Dowling, Kirsten G.

AU - Itkonen, Suvi Tuulikki

AU - Öhman, Taina

AU - Skaffari, Essi Johanna

AU - Saarnio, Elisa

AU - Kiely, Mairead

AU - Lamberg-Allardt, Christel Johanna Emilia

PY - 2019/9

Y1 - 2019/9

N2 - Context Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities.Objective To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations >= 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude.Methods We used data from a 5-month, winter-based, vitamin D-3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21-64-year old, living in Southern Finland (60 degrees N), to model the vitamin D intake-serum 25(OH)D dose-response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L.Results Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D >= 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 mu g/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds.Conclusion The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

AB - Context Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities.Objective To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations >= 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude.Methods We used data from a 5-month, winter-based, vitamin D-3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21-64-year old, living in Southern Finland (60 degrees N), to model the vitamin D intake-serum 25(OH)D dose-response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L.Results Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D >= 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 mu g/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds.Conclusion The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

KW - 416 Food Science

KW - 3143 Nutrition

KW - Vitamin D requirements

KW - Ethnic-related differences

KW - Dietary reference values

KW - RCT

KW - STANDARDIZATION PROGRAM PROTOCOLS

KW - 25-HYDROXYVITAMIN D DATA

KW - D SUPPLEMENTATION

KW - D DEFICIENCY

KW - DOSE-RESPONSE

KW - WHITE

KW - POPULATION

KW - IMMIGRANT

KW - PREVENTION

KW - AMERICANS

U2 - 10.1007/s00394-018-1775-1

DO - 10.1007/s00394-018-1775-1

M3 - Article

VL - 58

SP - 2281

EP - 2291

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 6

ER -