Effects of conjugated linoleic acid on linoleic and linoleic acid metabolism in man

Anu Turpeinen, Sonja Bärlund, Riitta Freese, Peter Lawrence, J. Thomas Brenna

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review


Evidence from animal studies suggests that conjugated linoleic acid (CLA) modulates plasma and tissue appearance of newly synthesized PUFA. The effects of a 1.2g (0.5 % energy) daily intake of the cis-9,trans-11 (c9,t11) isomer of CLA, trans-10,cis-12 (t10,c12) isomer of CLA or olive oil (placebo) on linoleic acid (LA) and linolenic acid (LNA) metabolism in healthy human volunteers was investigated. Fifteen subjects were fed an experimental diet and supplemented with c9,t11-CLA, t10,c12-CLA or placebo for 7 d before consuming a tracer dose of U-[C-13]LA (50 mg) and U-[C-13]LNA (50 mg). Blood samples were taken at 0, 2, 4, 6, 8, 24, 48, 72 and 168 h and analysed using high-precision MS. No differences between the groups in peak plasma [C-13]LA (10.3-11.6 % of dose), [C-13]LNA (2.5-2.9 % of dose), [C-13]arachidonic acid (0.09-0.12 % of dose), [C-13]EPA (0.04-0.06 % of dose) or [C-13]DHA (0.06-0.10 % of dose) were detected. Concentration v. time curves (area under the curve) also showed no significant differences between groups. This suggests that, in healthy human subjects consuming a diet with adequate intake of essential fatty acids, CLA does not affect metabolism of LA or LNA.
TidskriftBritish Journal of Nutrition
Sidor (från-till)727-733
Antal sidor7
StatusPublicerad - 2006
MoE-publikationstypA1 Tidskriftsartikel-refererad


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