Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children

Marja Roslund, Sonja Rantala, Sami Oikarinen, Riikka Puhakka, Nan Hui, Anirudra Parajuli, Olli-Heikki Laitinen, Heikki Hyöty, Anna-Lea Rantalainen, Aki Sinkkonen, The ADELE Research Group

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways.

To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments.

We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health.

Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

Originalspråkengelska
Artikelnummer104894
TidskriftEnvironment International
Volym130
Antal sidor8
ISSN0160-4120
DOI
StatusPublicerad - sep 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3142 Folkhälsovetenskap, miljö och arbetshälsa

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@article{38354ff0b3324a48affd6fc04fd21ea0,
title = "Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children",
abstract = "Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways.To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments.We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health.Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.",
keywords = "HEALTH, IMPACT, INDICATORS, INFLAMMATION, MICROBIOTA, MYCOBACTERIA, POLYCYCLIC AROMATIC-HYDROCARBONS, PPAR-GAMMA, SENSITIVITY, SEQUENCE DATA, 3142 Public health care science, environmental and occupational health",
author = "Marja Roslund and Sonja Rantala and Sami Oikarinen and Riikka Puhakka and Nan Hui and Anirudra Parajuli and Olli-Heikki Laitinen and Heikki Hy{\"o}ty and Anna-Lea Rantalainen and Aki Sinkkonen and {The ADELE Research Group}",
year = "2019",
month = "9",
doi = "10.1016/j.envint.2019.06.004",
language = "English",
volume = "130",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Scientific Publ. Co",

}

Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. / Roslund, Marja; Rantala, Sonja; Oikarinen, Sami; Puhakka, Riikka; Hui, Nan; Parajuli, Anirudra; Laitinen, Olli-Heikki; Hyöty, Heikki; Rantalainen, Anna-Lea; Sinkkonen, Aki; The ADELE Research Group.

I: Environment International, Vol. 130, 104894, 09.2019.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children

AU - Roslund, Marja

AU - Rantala, Sonja

AU - Oikarinen, Sami

AU - Puhakka, Riikka

AU - Hui, Nan

AU - Parajuli, Anirudra

AU - Laitinen, Olli-Heikki

AU - Hyöty, Heikki

AU - Rantalainen, Anna-Lea

AU - Sinkkonen, Aki

AU - The ADELE Research Group

PY - 2019/9

Y1 - 2019/9

N2 - Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways.To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments.We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health.Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

AB - Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways.To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments.We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health.Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

KW - HEALTH

KW - IMPACT

KW - INDICATORS

KW - INFLAMMATION

KW - MICROBIOTA

KW - MYCOBACTERIA

KW - POLYCYCLIC AROMATIC-HYDROCARBONS

KW - PPAR-GAMMA

KW - SENSITIVITY

KW - SEQUENCE DATA

KW - 3142 Public health care science, environmental and occupational health

U2 - 10.1016/j.envint.2019.06.004

DO - 10.1016/j.envint.2019.06.004

M3 - Article

VL - 130

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 104894

ER -