Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree

Petra Pekkarinen, J Terwilliger, Per Erik Bredbacka, Jouko Lönnqvist, Leena Peltonen

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Sammanfattning

An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder.

Originalspråkengelska
TidskriftGenome Research
Volym5
Sidor (från-till)105-115
Antal sidor11
ISSN1088-9051
StatusPublicerad - 1995
MoE-publikationstypA1 Tidskriftsartikel-refererad

Citera det här

Pekkarinen, P., Terwilliger, J., Bredbacka, P. E., Lönnqvist, J., & Peltonen, L. (1995). Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Research, 5, 105-115.