TY - JOUR
T1 - Functionalization of Carboxylated Lignin Nanoparticles for Targeted and pH-Responsive Delivery of Anticancer Drugs
AU - Figueiredo, Patricia Isabel
AU - Ferro, Claudio
AU - Kemell, Marianna Leena
AU - Liu, Zehua
AU - Kiriazis, Alexandros
AU - Lintinen, Kalle
AU - Florindo, Helena
AU - Yli-Kauhaluoma, Jari Tapani
AU - Hirvonen, Jouni Tapio
AU - A. Kostiainen , Mauri
AU - Almeida Santos, Helder
PY - 2017/10
Y1 - 2017/10
N2 - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.
AB - Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.
KW - 116 Chemical sciences
UR - https://www.futuremedicine.com/journal/nnm
U2 - 10.2217/nnm-2017-0219
DO - 10.2217/nnm-2017-0219
M3 - Article
VL - 12
SP - 2581
EP - 2596
JO - Nanomedicine
JF - Nanomedicine
SN - 1743-5889
IS - 21
ER -