Functionalization of Carboxylated Lignin Nanoparticles for Targeted and pH-Responsive Delivery of Anticancer Drugs

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Sammanfattning

Aim: To carboxylate kraft lignin toward the functionalization of carboxylated lignin nanoparticles (CLNPs) with a block copolymer made of PEG, poly(histidine) and a cell-penetrating peptide and then evaluate the chemotherapeutic potential of the innovative nanoparticles. Materials & methods: The produced nanoparticles were characterized and evaluated in vitro for stability and biocompatibility and the drug release profiles and antiproliferative effect were also assessed. Results: The prepared CLNPs showed spherical shape and good size distribution, good stability in physiological media and low cytotoxicity in all the tested cell lines. A poorly water-soluble cytotoxic agent was successfully loaded into the CLNPs, improving its release profiles in a pH-sensitive manner and showing an enhanced antiproliferative effect in the different cancer cells compared with a normal endothelial cell line. Conclusion: The resulting CLNPs are promising candidates for anticancer therapy.
Originalspråkengelska
TidskriftNanomedicine
Volym12
Utgåva21
Sidor (från-till)2581-2596
Antal sidor16
ISSN1743-5889
DOI
StatusPublicerad - okt 2017
MoE-publikationstypA1 Tidskriftsartikel-refererad

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