Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals

Francisca Araújo, José das Neves, Joao Pedro Oliveira Martins, Pedro L. Granja, Helder Almeida Santos, Bruno Sarmento

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

Sammanfattning

Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.
Originalspråkengelska
TidskriftProgress in Materials Science
Volym89
Sidor (från-till)306–344
Antal sidor39
ISSN0079-6425
DOI
StatusPublicerad - aug 2017
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 317 Farmaci

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title = "Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals",
abstract = "Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.",
keywords = "317 Pharmacy, Biomaterials , Multistage platforms , Biopharmaceuticals , Surface functionalization , Oral delivery",
author = "Francisca Ara{\'u}jo and {das Neves}, Jos{\'e} and {Oliveira Martins}, {Joao Pedro} and {L. Granja}, Pedro and {Almeida Santos}, Helder and Bruno Sarmento",
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Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals. / Araújo, Francisca ; das Neves, José ; Oliveira Martins, Joao Pedro; L. Granja, Pedro ; Almeida Santos, Helder; Sarmento, Bruno.

I: Progress in Materials Science, Vol. 89, 08.2017, s. 306–344.

Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

TY - JOUR

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AU - Araújo, Francisca

AU - das Neves, José

AU - Oliveira Martins, Joao Pedro

AU - L. Granja, Pedro

AU - Almeida Santos, Helder

AU - Sarmento, Bruno

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N2 - Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.

AB - Recent developments in materials science and specific surface functionalization of materials are providing new tools for the rational design of precisely engineered drug delivery systems. Particular interest has been paid to the exploitation of functionalized materials in the administration of biopharmaceuticals by the oral route, traditionally challenging and frequently compromised when using conventional pharmaceutical approaches. Using such materials for producing particulate systems is a common approach to obtain advanced drug delivery systems capable of providing stable and biocompatible environments and allowing for a targeted delivery of the associated biopharmaceuticals. This work intends to provide a thorough, up-to-date and holistic discussion on specific engineering and surface functionalization strategies of multistage platforms towards the development of novel delivery platforms for oral drug administration, with particular focus on the different materials and their interactions at the biological-material-host interface. This review will also address the safety and toxicity concerns of the resulting drug delivery systems, as well as their regulatory status and pathway towards the market approval of novel biopharmaceutical products based on particulate delivery systems.

KW - 317 Pharmacy

KW - Biomaterials

KW - Multistage platforms

KW - Biopharmaceuticals

KW - Surface functionalization

KW - Oral delivery

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