GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis

Hannah Larbalestier; Marcus Keatinge; Lisa Watson; Emma White; Siri Gowda; Wenbin Wei; Katjusa Koler; Svetlana A. Semenova; Adam M. Elkin; Neal Rimmer; Sean T. Sweeney; Julie Mazzolini; Dirk Sieger; Winston Hide; Jonathan McDearmid; Pertti Panula; Ryan B. MacDonald; Oliver Bandmann

doi:10.1523/JNEUROSCI.0653-21.2021

GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis

Hannah Larbalestier, Marcus Keatinge, Lisa Watson, Emma White, Siri Gowda, Wenbin Wei, Katjusa Koler, Svetlana A. Semenova, Adam M. Elkin, Neal Rimmer, Sean T. Sweeney, Julie Mazzolini, Dirk Sieger, Winston Hide, Jonathan McDearmid, Pertti Panula, Ryan B. MacDonald, Oliver Bandmann

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Journal of Neuroscience
Volym	42
Nummer	4
Sidor (från-till)	702-716
Antal sidor	15
ISSN	0270-6474
DOI	https://doi.org/10.1523/JNEUROSCI.0653-21.2021
Status	Publicerad - 26 jan. 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3112 Neurovetenskaper
3124 Neurologi och psykiatri

Åtkomst av dokument

10.1523/JNEUROSCI.0653-21.2021

GCH1 deficiency activates brain innate ..Accepterat manuskript från författare, 7,68 MB

Citera det här

Larbalestier, H., Keatinge, M., Watson, L., White, E., Gowda, S., Wei, W., Koler, K., Semenova, S. A., Elkin, A. M., Rimmer, N., Sweeney, S. T., Mazzolini, J., Sieger, D., Hide, W., McDearmid, J., Panula, P., MacDonald, R. B., & Bandmann, O. (2022). GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis. Journal of Neuroscience, 42(4), 702-716. https://doi.org/10.1523/JNEUROSCI.0653-21.2021

@article{015ac9489d0d4d95b4188c38feb94c99,

title = "GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis",

keywords = "Parkinson's disease, GTP cyclohydrolase 1, tetrahydrobiopterin, zebrafish, tyrosine hydroxylase, microglia, GTP CYCLOHYDROLASE-I, GENOME-WIDE ASSOCIATION, PARKINSONS-DISEASE, MICROGLIAL ACTIVATION, SUBSTANTIA-NIGRA, NITRIC-OXIDE, RISK LOCI, DYSTONIA, DOPAMINE, MODEL, 3112 Neurosciences, 3124 Neurology and psychiatry",

author = "Hannah Larbalestier and Marcus Keatinge and Lisa Watson and Emma White and Siri Gowda and Wenbin Wei and Katjusa Koler and Semenova, {Svetlana A.} and Elkin, {Adam M.} and Neal Rimmer and Sweeney, {Sean T.} and Julie Mazzolini and Dirk Sieger and Winston Hide and Jonathan McDearmid and Pertti Panula and MacDonald, {Ryan B.} and Oliver Bandmann",

year = "2022",

month = jan,

day = "26",

doi = "10.1523/JNEUROSCI.0653-21.2021",

language = "English",

volume = "42",

pages = "702--716",

journal = "Journal of Neuroscience",

issn = "0270-6474",

publisher = "Society of Neuroscience",

number = "4",

}

Larbalestier, H, Keatinge, M, Watson, L, White, E, Gowda, S, Wei, W, Koler, K, Semenova, SA, Elkin, AM, Rimmer, N, Sweeney, ST, Mazzolini, J, Sieger, D, Hide, W, McDearmid, J, Panula, P, MacDonald, RB & Bandmann, O 2022, 'GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis', Journal of Neuroscience, vol. 42, nr. 4, s. 702-716. https://doi.org/10.1523/JNEUROSCI.0653-21.2021

TY - JOUR

T1 - GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis

AU - Larbalestier, Hannah

AU - Keatinge, Marcus

AU - Watson, Lisa

AU - White, Emma

AU - Gowda, Siri

AU - Wei, Wenbin

AU - Koler, Katjusa

AU - Semenova, Svetlana A.

AU - Elkin, Adam M.

AU - Rimmer, Neal

AU - Sweeney, Sean T.

AU - Mazzolini, Julie

AU - Sieger, Dirk

AU - Hide, Winston

AU - McDearmid, Jonathan

AU - Panula, Pertti

AU - MacDonald, Ryan B.

AU - Bandmann, Oliver

PY - 2022/1/26

Y1 - 2022/1/26

KW - Parkinson's disease

KW - GTP cyclohydrolase 1

KW - tetrahydrobiopterin

KW - zebrafish

KW - tyrosine hydroxylase

KW - microglia

KW - GTP CYCLOHYDROLASE-I

KW - GENOME-WIDE ASSOCIATION

KW - PARKINSONS-DISEASE

KW - MICROGLIAL ACTIVATION

KW - SUBSTANTIA-NIGRA

KW - NITRIC-OXIDE

KW - RISK LOCI

KW - DYSTONIA

KW - DOPAMINE

KW - MODEL

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

U2 - 10.1523/JNEUROSCI.0653-21.2021

DO - 10.1523/JNEUROSCI.0653-21.2021

M3 - Article

VL - 42

SP - 702

EP - 716

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 4

ER -