Gene therapy of gynaecological diseases: [review]

    Forskningsoutput: TidskriftsbidragÖversiktsartikelVetenskapligPeer review

    Sammanfattning

    Gene therapy represents a potentially useful approach for the treatment of diseases refractory to conventional therapies. Various preclinical and clinical strategies have been explored for treatment of gynaecological diseases. Given the most severe unmet clinical need, much of the work has been performed with gynaecological cancers and ovarian cancer in particular. Although the safety of many treatment strategies has been demonstrated in early phase clinical trials, efficacy has been mostly limited heretofore. Major challenges include improving the vectors used with the aim of more effective and selective delivery. In addition, effective penetration into and spreading within advanced and complex tumour masses and metastases remains challenging. This review focuses on existing and developmental gene transfer applications for gynaecological diseases.
    Originalspråkengelska
    TidskriftExpert Opinion on Biological Therapy
    Volym7
    Utgåva9
    Sidor (från-till)1347-1361
    Antal sidor15
    ISSN1471-2598
    DOI
    StatusPublicerad - 2007
    MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

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