In degenerative diseases, microenvironment deterioration is often followed by a vicious circle of cell death and aggravation of microenvironment deterioration. To break the cycle, a gene‐hydrogel microenvironment is constructed in article number 1902099 by Yuhui Zhang, Hélder A. Santos, Hongxing Shen, and co‐workers in situ, which regulates the synthesis/catabolism balance of extracellular matrix in the nucleus pulposus of the intervertebral disc and improves the tissue microenvironment regeneration.
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Chen, W., Chen, H., Zheng, D., Zhang, H., Deng, L., Cui, W., ... Shen, H. (2020). Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020). Advanced Science, 7(1), 2070001. https://doi.org/10.1002/advs.202070001