Genetic component of identification, intensity and pleasantness of odours: a Finnish family study

Antti Knaapila, Kaisu Keskitalo, Mikko Kallela, Maija Wessman, Sampo Sammalisto, Tero Hiekkalinna, Aarno Palotie, Leena Peltonen, Hely Tuorila, Markus Perola

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Although potential odorant receptor genes have been identified, the precise genetic component of perception of odours is still obscure. Although there is some evidence for heritability of a few olfactory-related traits, no genome-wide search for loci harboring underlying genes has been published to date. We performed a genome-wide scan to identify loci affecting the identification, intensity and pleasantness of 12 odours ( cinnamon, turpentine, lemon, smoke, chocolate, rose, paint thinner, banana, pineapple, gasoline, soap, onion) using 146 Finnish adults from 26 families. Several of these traits showed heritable variation in the families. Suggestive evidence of linkage was found for the pleasantness of cinnamon odour (h(2) = 61%) on chromosome 4q32.3 (multipoint logarithm of the odds ( LOD) score 3.01), as well as for the perceived intensity of paint thinner odour (h(2) = 31%) on chromosome 2p14 (multipoint LOD score 2.55). As these loci do not contain any known human odorant receptor genes, they may rather harbor genes that affect the central processing than the peripheral detection of the odour signal. Thus, perception of odours is potentially modified by genes other than those encoding odorant receptors.
Originalspråkengelska
TidskriftEuropean Journal of Human Genetics
Volym15
Utgåva5
Sidor (från-till)596-602
Antal sidor7
ISSN1018-4813
DOI
StatusPublicerad - 2007
MoE-publikationstypA1 Tidskriftsartikel-refererad

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