Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä, Teemu Niiranen, Antti Jula, Ilkka Pörsti, Antti J. Tikkakoski, Aki Havulinna, Terho Lehtimäki, Veikko Salomaa, Kimmo K. Kontula, Timo P. Hiltunen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

Originalspråkengelska
TidskriftBlood Pressure
Volym28
Utgåva4
Sidor (från-till)239-249
Antal sidor11
ISSN0803-7051
DOI
StatusPublicerad - 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad

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