Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä; Teemu Niiranen; Antti Jula; Ilkka Pörsti; Antti J. Tikkakoski; Aki Havulinna; Terho Lehtimäki; Veikko Salomaa; Kimmo K. Kontula; Timo P. Hiltunen

doi:10.1080/08037051.2019.1604066

Genome-wide association study of white-coat effect in hypertensive patients

Jenni M. Rimpelä, Teemu Niiranen, Antti Jula, Ilkka Pörsti, Antti J. Tikkakoski, Aki Havulinna, Terho Lehtimäki, Veikko Salomaa, Kimmo K. Kontula, Timo P. Hiltunen

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

Originalspråk	engelska
Tidskrift	Blood Pressure
Volym	28
Utgåva	4
Sidor (från-till)	239-249
Antal sidor	11
ISSN	0803-7051
DOI	https://doi.org/10.1080/08037051.2019.1604066
Status	Publicerad - 2019
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3121 Inre medicin

Åtkomst av dokument

10.1080/08037051.2019.1604066

Citera det här

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title = "Genome-wide association study of white-coat effect in hypertensive patients",

abstract = "Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values",

keywords = "3121 Internal medicine, White-coat effect, hypertension, gene, genome-wide, SPG7, RASGEF1B, BLOOD-PRESSURE, MASKED HYPERTENSION, GENERAL-POPULATION, GENETIC-VARIANTS, HOME, METAANALYSIS, NEUROTICISM, PREDICTORS",

author = "Rimpel{\"a}, {Jenni M.} and Teemu Niiranen and Antti Jula and Ilkka P{\"o}rsti and Tikkakoski, {Antti J.} and Aki Havulinna and Terho Lehtim{\"a}ki and Veikko Salomaa and Kontula, {Kimmo K.} and Hiltunen, {Timo P.}",

year = "2019",

doi = "10.1080/08037051.2019.1604066",

language = "English",

volume = "28",

pages = "239--249",

journal = "Blood Pressure",

issn = "0803-7051",

publisher = "Taylor & Francis",

number = "4",

}

Genome-wide association study of white-coat effect in hypertensive patients. / Rimpelä, Jenni M.; Niiranen, Teemu; Jula, Antti; Pörsti, Ilkka; Tikkakoski, Antti J.; Havulinna, Aki; Lehtimäki, Terho; Salomaa, Veikko; Kontula, Kimmo K.; Hiltunen, Timo P.

I: Blood Pressure, Vol. 28, Nr. 4, 2019, s. 239-249.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Genome-wide association study of white-coat effect in hypertensive patients

AU - Rimpelä, Jenni M.

AU - Niiranen, Teemu

AU - Jula, Antti

AU - Pörsti, Ilkka

AU - Tikkakoski, Antti J.

AU - Havulinna, Aki

AU - Lehtimäki, Terho

AU - Salomaa, Veikko

AU - Kontula, Kimmo K.

AU - Hiltunen, Timo P.

PY - 2019

Y1 - 2019

N2 - Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

AB - Background: White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role.Methods: To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort (n=206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with p values

KW - 3121 Internal medicine

KW - White-coat effect

KW - hypertension

KW - gene

KW - genome-wide

KW - SPG7

KW - RASGEF1B

KW - BLOOD-PRESSURE

KW - MASKED HYPERTENSION

KW - GENERAL-POPULATION

KW - GENETIC-VARIANTS

KW - HOME

KW - METAANALYSIS

KW - NEUROTICISM

KW - PREDICTORS

U2 - 10.1080/08037051.2019.1604066

DO - 10.1080/08037051.2019.1604066

M3 - Article

VL - 28

SP - 239

EP - 249

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 4

ER -