Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Yuhao Fu, Qingyuan Dou, Kornelia Smalla, Yu Wang, Timothy A. Johnson, Kristian K. Brandt, Zhi Mei, Maoyuan Liao, Syed A. Hashsham, Andreas Schäffer, Hauke Smidt, Tong Zhang, Hui Li, Robert Stedtfeld, Hongjie Sheng, Benli Chai, Marko Virta, Xin Jiang, Fang Wang, Yong Guan ZhuJames M. Tiedje

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

The emergence and rapid spread of antimicrobial resistance is of global public health concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that can acquire resistance via horizontal and vertical gene transfers is considered an important reservoir and sink of antibiotic resistance genes (ARGs). In this review, we describe the reservoirs of gut ARGs and their dynamics in both animals and humans, use the One Health perspective to track the transmission of ARG-containing bacteria between humans, animals, and the environment, and assess the impact of antimicrobial resistance on human health and socioeconomic development. The gut resistome can evolve in an environment subject to various selective pressures, including antibiotic administration and environmental and lifestyle factors (e.g., diet, age, gender, and living conditions), and interventions through probiotics. Strategies to reduce the abundance of clinically relevant antibiotic-resistant bacteria and their resistance determinants in various environmental niches are needed to ensure the mitigation of acquired antibiotic resistance. With the help of effective measures taken at the national, local, personal, and intestinal management, it will also result in preventing or minimizing the spread of infectious diseases. This review aims to improve our understanding of the correlations between intestinal microbiota and antimicrobial resistance and provide a basis for the development of management strategies to mitigate the antimicrobial resistance crisis.

Originalspråkengelska
TidskriftmLife
Volym2
Nummer4
Sidor (från-till)350-364
Antal sidor15
ISSN2097-1699
DOI
StatusPublicerad - dec. 2023
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Bibliografisk information

Publisher Copyright:
© 2023 The Authors. mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute of Microbiology, Chinese Academy of Sciences.

Vetenskapsgrenar

  • 11832 Mikrobiologi och virologi

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