Hydroxypropyl methylcellulose-controlled crystallization of erythromycin A dihydrate crystals with modified morphology

Sabiruddin Mirza, Inna Miroshnyk, Jyrki Heinämäki, Jukka Rantanen, Osmo Antikainen, Pia Vuorela, Heikki Vuorela, Jouko Yliruusi

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    Crystallization in the presence of pharmaceutically accepted excipients as additives was investigated as a tool for morphological crystal engineering of active pharmaceutical ingredients. Recrystallization of a model drug substance, erythromycin A dihydrate, was carried out by a precipitation technique in the presence of varying amount of hydroxypropyl methylcellulose (HPMC). In contrast to the reference crystals, the crystals grown in the presence of HPMC exhibited regular shape, which varied with the concentration of the additive present, thus indicating that HPMC is an effective habit modifier for erythromycin A dihydrate. On the basis of the crystal surface chemistry, the mechanism responsible for the change in morphology is proposed. Finally, the effect of crystal habit modification on compaction behavior of erythromycin A dihydrate is demonstrated.
    Originalspråkengelska
    TidskriftCrystal Growth & Design
    Volym8
    Utgåva10
    Sidor (från-till)3526-3531
    Antal sidor6
    ISSN1528-7483
    DOI
    StatusPublicerad - 2008
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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