ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain

Carl G Gahmberg, Li Tian, Lin Ning, Henrietta Nyman-Huttunen

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.
    Originalspråkengelska
    TidskriftImmunology Letters
    Volym117
    Utgåva2
    Sidor (från-till)131-135
    Antal sidor5
    ISSN0165-2478
    DOI
    StatusPublicerad - 2008
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Citera det här

    Gahmberg, Carl G ; Tian, Li ; Ning, Lin ; Nyman-Huttunen, Henrietta. / ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain. I: Immunology Letters. 2008 ; Vol. 117, Nr. 2. s. 131-135.
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    title = "ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain",
    abstract = "Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.",
    author = "Gahmberg, {Carl G} and Li Tian and Lin Ning and Henrietta Nyman-Huttunen",
    year = "2008",
    doi = "10.1016/j.imlet.2008.02.004",
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    ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain. / Gahmberg, Carl G; Tian, Li; Ning, Lin; Nyman-Huttunen, Henrietta.

    I: Immunology Letters, Vol. 117, Nr. 2, 2008, s. 131-135.

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    TY - JOUR

    T1 - ICAM-5 - A novel two-facetted adhesion molecule in the mammalian brain

    AU - Gahmberg, Carl G

    AU - Tian, Li

    AU - Ning, Lin

    AU - Nyman-Huttunen, Henrietta

    PY - 2008

    Y1 - 2008

    N2 - Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.

    AB - Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.

    U2 - 10.1016/j.imlet.2008.02.004

    DO - 10.1016/j.imlet.2008.02.004

    M3 - Article

    VL - 117

    SP - 131

    EP - 135

    JO - Immunology Letters

    JF - Immunology Letters

    SN - 0165-2478

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    ER -