Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation

Esa Jantunen, Antti Turunen, Ville Varmavuo, Anu Partanen

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Plerixafor (PLER), a reversible antagonist of the CXC chemokine receptor type 4, has been in clinical use for mobilization of blood grafts for autologous hematopoietic cell transplantation (AHCT) for about 15 years. Initially PLER was investigated in placebo-controlled trials with the granulocyte colony-stimulating factor (G-CSF) filgrastim. It has also been used in combination with chemotherapy plus G-CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This review summarizes what is known regarding addition of PLER to standard mobilization regimens. PLER increases mobilization of CD34+ cells, decreases the number of apheresis sessions needed to achieve collection targets and increases the proportion of patients who can proceed to AHCT. It appears also to increase the amount of various lymphocyte subsets in the grafts collected. In general, hematologic recovery after AHCT has been comparable to patients mobilized without PLER, although slower platelet recovery has been observed in some studies of patients who mobilize poorly. In phase III studies, long-term outcome has been comparable to patients mobilized without PLER. This also appears to be the case in patients receiving plerixafor for poor or suboptimal mobilization of CD34+ cells. In practice, PLER is safe and has not been shown to increase tumor cell mobilization.

Originalspråkengelska
TidskriftTransfusion
Volym64
Nummer4
Sidor (från-till)742-750
Antal sidor9
ISSN0041-1132
DOI
StatusPublicerad - apr. 2024
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Bibliografisk information

Publisher Copyright:
© 2024 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.

Vetenskapsgrenar

  • 3121 Allmänmedicin, inre medicin och annan klinisk medicin

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