Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions

Anne Toivanen, Eveliina Ihanus, Minna Mattila, Hans U Lutz, Carl G Gahmberg

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    Several blood groups, including the LW-blood group were discovered in the first part of last century, but their biochemical characteristics and cellular functions have only more recently been elucidated. The LW-blood group, renamed ICAM-4 (CD242), is red cell specific and belongs to the intercellular adhesion molecule family. ICAM-4 binds to several integrin receptors on blood and endothelial cells and is thus able to form large cellular complexes containing red cells. Its physiological function(s) has remained incompletely understood, but recent work shows that macrophage integrins can bind red cells through this ligand. In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-itegrin dependent. (c) 2007 Elsevier B.V. All rights reserved.
    Originalspråkengelska
    TidskriftBiochimica et Biophysica Acta. General Subjects
    Volym1780
    Sidor (från-till)456-466
    Antal sidor11
    ISSN0304-4165
    DOI
    StatusPublicerad - 2008
    MoE-publikationstypA1 Tidskriftsartikel-refererad

    Vetenskapsgrenar

    • 1182 Biokemi, cell- och molekylärbiologi
    • 3111 Biomedicinska vetenskaper

    Citera det här

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    title = "Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions",
    abstract = "Several blood groups, including the LW-blood group were discovered in the first part of last century, but their biochemical characteristics and cellular functions have only more recently been elucidated. The LW-blood group, renamed ICAM-4 (CD242), is red cell specific and belongs to the intercellular adhesion molecule family. ICAM-4 binds to several integrin receptors on blood and endothelial cells and is thus able to form large cellular complexes containing red cells. Its physiological function(s) has remained incompletely understood, but recent work shows that macrophage integrins can bind red cells through this ligand. In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-itegrin dependent. (c) 2007 Elsevier B.V. All rights reserved.",
    keywords = "1182 Biochemistry, cell and molecular biology, 3111 Biomedicine",
    author = "Anne Toivanen and Eveliina Ihanus and Minna Mattila and Lutz, {Hans U} and Gahmberg, {Carl G}",
    year = "2008",
    doi = "10.1016/j.bbagen.2007.09.003",
    language = "English",
    volume = "1780",
    pages = "456--466",
    journal = "Biochimica et Biophysica Acta. General Subjects",
    issn = "0304-4165",
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    Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions. / Toivanen, Anne; Ihanus, Eveliina; Mattila, Minna; Lutz, Hans U; Gahmberg, Carl G.

    I: Biochimica et Biophysica Acta. General Subjects, Vol. 1780, 2008, s. 456-466.

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    TY - JOUR

    T1 - Importance of molecular studies on major blood groups - intercellular adhesion molecule-4, a blood group antigen involved in multiple cellular interactions

    AU - Toivanen, Anne

    AU - Ihanus, Eveliina

    AU - Mattila, Minna

    AU - Lutz, Hans U

    AU - Gahmberg, Carl G

    PY - 2008

    Y1 - 2008

    N2 - Several blood groups, including the LW-blood group were discovered in the first part of last century, but their biochemical characteristics and cellular functions have only more recently been elucidated. The LW-blood group, renamed ICAM-4 (CD242), is red cell specific and belongs to the intercellular adhesion molecule family. ICAM-4 binds to several integrin receptors on blood and endothelial cells and is thus able to form large cellular complexes containing red cells. Its physiological function(s) has remained incompletely understood, but recent work shows that macrophage integrins can bind red cells through this ligand. In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-itegrin dependent. (c) 2007 Elsevier B.V. All rights reserved.

    AB - Several blood groups, including the LW-blood group were discovered in the first part of last century, but their biochemical characteristics and cellular functions have only more recently been elucidated. The LW-blood group, renamed ICAM-4 (CD242), is red cell specific and belongs to the intercellular adhesion molecule family. ICAM-4 binds to several integrin receptors on blood and endothelial cells and is thus able to form large cellular complexes containing red cells. Its physiological function(s) has remained incompletely understood, but recent work shows that macrophage integrins can bind red cells through this ligand. In this article we discuss molecular properties of major blood group antigens, describe ICAM-4 in more detail, and show that phagocytosis of senescent red cells is in part ICAM-4/beta(2)-itegrin dependent. (c) 2007 Elsevier B.V. All rights reserved.

    KW - 1182 Biochemistry, cell and molecular biology

    KW - 3111 Biomedicine

    U2 - 10.1016/j.bbagen.2007.09.003

    DO - 10.1016/j.bbagen.2007.09.003

    M3 - Article

    VL - 1780

    SP - 456

    EP - 466

    JO - Biochimica et Biophysica Acta. General Subjects

    JF - Biochimica et Biophysica Acta. General Subjects

    SN - 0304-4165

    ER -