Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Marianna Hellén; Isabelle Weert; Stephan A. Müller; Noora Räsänen; Pinja Kettunen; Sarka Lehtonen; Michael Peitz; Klaus Fliessbach; Mari Takalo; Marja Koskuvi; Stefan F. Lichtenthaler; Ville Leinonen; Alfredo Ramirez; Olli Karkkainen; Mikko Hiltunen; Jari Koistinaho; Taisia Rolova

doi:10.1186/s12974-025-03470-y

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Marianna Hellén
, Isabelle Weert
, Stephan A. Müller
, Noora Räsänen
, Pinja Kettunen
, Sarka Lehtonen
, Michael Peitz
, Klaus Fliessbach
, Mari Takalo
, Marja Koskuvi
, Stefan F. Lichtenthaler
, Ville Leinonen
, Alfredo Ramirez
, Olli Karkkainen
, Mikko Hiltunen
, Jari Koistinaho
, Taisia Rolova

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	147
Tidskrift	Journal of Neuroinflammation
Volym	22
Nummer	1
Antal sidor	18
ISSN	1742-2094
DOI	https://doi.org/10.1186/s12974-025-03470-y
Status	Publicerad - 2 juni 2025
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3112 Neurovetenskaper

Åtkomst av dokument

10.1186/s12974-025-03470-yLicens: CC BY

http://hdl.handle.net/10138/596933Licens: CC BY

Citera det här

Hellén, M., Weert, I., Müller, S. A., Räsänen, N., Kettunen, P., Lehtonen, S., Peitz, M., Fliessbach, K., Takalo, M., Koskuvi, M., Lichtenthaler, S. F., Leinonen, V., Ramirez, A., Karkkainen, O., Hiltunen, M., Koistinaho, J., & Rolova, T. (2025). Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype. Journal of Neuroinflammation, 22(1), Artikel 147. https://doi.org/10.1186/s12974-025-03470-y

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title = "Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype",

keywords = "Alzheimer's disease, Apolipoprotein E, Lysosomal dysfunction, Microglia, iPSC, 3112 Neurosciences",

author = "Marianna Hell{\'e}n and Isabelle Weert and M{\"u}ller, \{Stephan A.\} and Noora R{\"a}s{\"a}nen and Pinja Kettunen and Sarka Lehtonen and Michael Peitz and Klaus Fliessbach and Mari Takalo and Marja Koskuvi and Lichtenthaler, \{Stefan F.\} and Ville Leinonen and Alfredo Ramirez and Olli Karkkainen and Mikko Hiltunen and Jari Koistinaho and Taisia Rolova",

year = "2025",

month = jun,

day = "2",

doi = "10.1186/s12974-025-03470-y",

language = "English",

volume = "22",

journal = "Journal of Neuroinflammation",

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Hellén, M, Weert, I, Müller, SA, Räsänen, N , Kettunen, P , Lehtonen, S, Peitz, M, Fliessbach, K, Takalo, M, Koskuvi, M, Lichtenthaler, SF, Leinonen, V, Ramirez, A, Karkkainen, O, Hiltunen, M, Koistinaho, J & Rolova, T 2025, 'Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype', Journal of Neuroinflammation, vol. 22, nr. 1, 147. https://doi.org/10.1186/s12974-025-03470-y

TY - JOUR

T1 - Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

AU - Hellén, Marianna

AU - Weert, Isabelle

AU - Müller, Stephan A.

AU - Räsänen, Noora

AU - Kettunen, Pinja

AU - Lehtonen, Sarka

AU - Peitz, Michael

AU - Fliessbach, Klaus

AU - Takalo, Mari

AU - Koskuvi, Marja

AU - Lichtenthaler, Stefan F.

AU - Leinonen, Ville

AU - Ramirez, Alfredo

AU - Karkkainen, Olli

AU - Hiltunen, Mikko

AU - Koistinaho, Jari

AU - Rolova, Taisia

PY - 2025/6/2

Y1 - 2025/6/2

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Lysosomal dysfunction

KW - Microglia

KW - iPSC

KW - 3112 Neurosciences

U2 - 10.1186/s12974-025-03470-y

DO - 10.1186/s12974-025-03470-y

M3 - Article

C2 - 40457456

SN - 1742-2094

VL - 22

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

IS - 1

M1 - 147

ER -