Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

Kristian Semjonov; Maia Salm; Tiina Lipiäinen; Karin Kogermann; Andres Lust; Ivo Laidmäe; Osmo Antikainen; Clare J. Strachan; Henrik Ehlers; Jouko Yliruusi; Jyrki Heinämäki

doi:10.1016/j.ijpharm.2018.02.039

Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

Kristian Semjonov, Maia Salm, Tiina Lipiäinen, Karin Kogermann, Andres Lust, Ivo Laidmäe, Osmo Antikainen, Clare J. Strachan, Henrik Ehlers, Jouko Yliruusi, Jyrki Heinämäki

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	International Journal of Pharmaceutics
Volym	541
Utgåva	1-2
Sidor (från-till)	188-197
Antal sidor	10
ISSN	0378-5173
DOI	https://doi.org/10.1016/j.ijpharm.2018.02.039
Status	Publicerad - 25 apr 2018
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

317 Farmaci

Åtkomst av dokument

10.1016/j.ijpharm.2018.02.039

1-s2.0-S0378517318301200-mainAccepterat manuskript från författare, 743 KBLicens: CC BY-NC-ND

Citera det här

Semjonov, K., Salm, M., Lipiäinen, T., Kogermann, K., Lust, A., Laidmäe, I., Antikainen, O., Strachan, C. J., Ehlers, H., Yliruusi, J., & Heinämäki, J. (2018). Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions. International Journal of Pharmaceutics, 541(1-2), 188-197. https://doi.org/10.1016/j.ijpharm.2018.02.039

Semjonov, Kristian ; Salm, Maia ; Lipiäinen, Tiina ; Kogermann, Karin ; Lust, Andres ; Laidmäe, Ivo ; Antikainen, Osmo ; Strachan, Clare J. ; Ehlers, Henrik ; Yliruusi, Jouko ; Heinämäki, Jyrki. / Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions. I: International Journal of Pharmaceutics. 2018 ; Vol. 541, Nr. 1-2. s. 188-197.

@article{2982b8591dab4eaf900ba3d89106a773,

title = "Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions",

keywords = "particle properties, bulk powder behavior, dissolution, solid dispersion, polymer, HOT-MELT EXTRUSION, WATER-SOLUBLE DRUG, AMORPHOUS INDOMETHACIN, DISSOLUTION RATE, PHYSICAL STABILITY, MIXTURES, SIZE, BIOAVAILABILITY, FLOWABILITY, FORMULATION, 317 Pharmacy",

author = "Kristian Semjonov and Maia Salm and Tiina Lipi{\"a}inen and Karin Kogermann and Andres Lust and Ivo Laidm{\"a}e and Osmo Antikainen and Strachan, {Clare J.} and Henrik Ehlers and Jouko Yliruusi and Jyrki Hein{\"a}m{\"a}ki",

year = "2018",

month = apr,

day = "25",

doi = "10.1016/j.ijpharm.2018.02.039",

language = "English",

volume = "541",

pages = "188--197",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier Scientific Publ. Co",

number = "1-2",

}

Semjonov, K, Salm, M, Lipiäinen, T, Kogermann, K, Lust, A, Laidmäe, I, Antikainen, O , Strachan, CJ, Ehlers, H, Yliruusi, J & Heinämäki, J 2018, 'Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions', International Journal of Pharmaceutics, vol. 541, nr. 1-2, s. 188-197. https://doi.org/10.1016/j.ijpharm.2018.02.039

Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions. / Semjonov, Kristian; Salm, Maia; Lipiäinen, Tiina; Kogermann, Karin; Lust, Andres; Laidmäe, Ivo; Antikainen, Osmo ; Strachan, Clare J.; Ehlers, Henrik; Yliruusi, Jouko ; Heinämäki, Jyrki.

I: International Journal of Pharmaceutics, Vol. 541, Nr. 1-2, 25.04.2018, s. 188-197.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Interdependence of particle properties and bulk powder behavior of indomethacin in quench-cooled molten two-phase solid dispersions

AU - Semjonov, Kristian

AU - Salm, Maia

AU - Lipiäinen, Tiina

AU - Kogermann, Karin

AU - Lust, Andres

AU - Laidmäe, Ivo

AU - Antikainen, Osmo

AU - Strachan, Clare J.

AU - Ehlers, Henrik

AU - Yliruusi, Jouko

AU - Heinämäki, Jyrki

PY - 2018/4/25

Y1 - 2018/4/25

KW - particle properties

KW - bulk powder behavior

KW - dissolution

KW - solid dispersion

KW - polymer

KW - HOT-MELT EXTRUSION

KW - WATER-SOLUBLE DRUG

KW - AMORPHOUS INDOMETHACIN

KW - DISSOLUTION RATE

KW - PHYSICAL STABILITY

KW - MIXTURES

KW - SIZE

KW - BIOAVAILABILITY

KW - FLOWABILITY

KW - FORMULATION

KW - 317 Pharmacy

U2 - 10.1016/j.ijpharm.2018.02.039

DO - 10.1016/j.ijpharm.2018.02.039

M3 - Article

VL - 541

SP - 188

EP - 197

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -