Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Tobias L. Freitag; Riku Fagerlund; Nihay Laham Karam; Veli-Matti Leppänen; Hasan Ugurlu; Ravi Kant; Petri Mäkinen; Ahmed Tawfek; Sawan Kumar Jha; Tomas Strandin; Katarzyna Leskinen; Jussi Hepojoki; Tapio Kesti; Lauri Kareinen; Suvi Kuivanen; Emma Koivulehto; Aino Sormunen; Svetlana Laidinen; Ayman Khattab; Päivi Saavalainen; Seppo Meri; Anja Kipar; Tarja Sironen; Olli Vapalahti; Kari Alitalo; Seppo Ylä-Herttuala; Kalle Saksela

doi:10.1016/j.vaccine.2023.04.020

Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

Tobias L. Freitag, Riku Fagerlund, Nihay Laham Karam, Veli-Matti Leppänen, Hasan Ugurlu, Ravi Kant, Petri Mäkinen, Ahmed Tawfek, Sawan Kumar Jha, Tomas Strandin, Katarzyna Leskinen, Jussi Hepojoki, Tapio Kesti, Lauri Kareinen, Suvi Kuivanen, Emma Koivulehto, Aino Sormunen, Svetlana Laidinen, Ayman Khattab, Päivi SaavalainenSeppo Meri, Anja Kipar, Tarja Sironen, Olli Vapalahti, Kari Alitalo, Seppo Ylä-Herttuala, Kalle Saksela

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Vaccine
Volym	41
Nummer	20
Sidor (från-till)	3233-3246
Antal sidor	14
ISSN	0264-410X
DOI	https://doi.org/10.1016/j.vaccine.2023.04.020
Status	Publicerad - 11 maj 2023
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3111 Biomedicinska vetenskaper
11832 Mikrobiologi och virologi

Åtkomst av dokument

10.1016/j.vaccine.2023.04.020

1-s2.0-S0264410X23004036-mainSlutlig publicerad version, 1,99 MBLicens: CC BY

Citera det här

Freitag, T. L., Fagerlund, R., Karam, N. L., Leppänen, V-M., Ugurlu, H., Kant, R., Mäkinen, P., Tawfek, A., Kumar Jha, S., Strandin, T., Leskinen, K., Hepojoki, J., Kesti, T., Kareinen, L., Kuivanen, S., Koivulehto, E., Sormunen, A., Laidinen, S., Khattab, A., ... Saksela, K. (2023). Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models. Vaccine, 41(20), 3233-3246. https://doi.org/10.1016/j.vaccine.2023.04.020

@article{4514dda038614c71975190ff884993b0,

title = "Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models",

keywords = "SARS-CoV-2, COVID-19, intranasal vaccination, mucosal immunity, adenoviral vector, Mucosal immunity, Covid-19, Adenoviral vector, Intranasal vaccination, 3111 Biomedicine, 11832 Microbiology and virology",

author = "Freitag, {Tobias L.} and Riku Fagerlund and Karam, {Nihay Laham} and Veli-Matti Lepp{\"a}nen and Hasan Ugurlu and Ravi Kant and Petri M{\"a}kinen and Ahmed Tawfek and {Kumar Jha}, Sawan and Tomas Strandin and Katarzyna Leskinen and Jussi Hepojoki and Tapio Kesti and Lauri Kareinen and Suvi Kuivanen and Emma Koivulehto and Aino Sormunen and Svetlana Laidinen and Ayman Khattab and P{\"a}ivi Saavalainen and Seppo Meri and Anja Kipar and Tarja Sironen and Olli Vapalahti and Kari Alitalo and Seppo Yl{\"a}-Herttuala and Kalle Saksela",

year = "2023",

month = may,

day = "11",

doi = "10.1016/j.vaccine.2023.04.020",

language = "English",

volume = "41",

pages = "3233--3246",

journal = "Vaccine",

issn = "0264-410X",

publisher = "ELSEVIER SCI IRELAND LTD",

number = "20",

}

Freitag, TL , Fagerlund, R, Karam, NL, Leppänen, V-M , Ugurlu, H , Kant, R, Mäkinen, P, Tawfek, A, Kumar Jha, S , Strandin, T, Leskinen, K, Hepojoki, J, Kesti, T, Kareinen, L , Kuivanen, S, Koivulehto, E, Sormunen, A, Laidinen, S, Khattab, A , Saavalainen, P , Meri, S, Kipar, A, Sironen, T , Vapalahti, O , Alitalo, K, Ylä-Herttuala, S & Saksela, K 2023, 'Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models', Vaccine, vol. 41, nr. 20, s. 3233-3246. https://doi.org/10.1016/j.vaccine.2023.04.020

TY - JOUR

T1 - Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

AU - Freitag, Tobias L.

AU - Fagerlund, Riku

AU - Karam, Nihay Laham

AU - Leppänen, Veli-Matti

AU - Ugurlu, Hasan

AU - Kant, Ravi

AU - Mäkinen, Petri

AU - Tawfek, Ahmed

AU - Kumar Jha, Sawan

AU - Strandin, Tomas

AU - Leskinen, Katarzyna

AU - Hepojoki, Jussi

AU - Kesti, Tapio

AU - Kareinen, Lauri

AU - Kuivanen, Suvi

AU - Koivulehto, Emma

AU - Sormunen, Aino

AU - Laidinen, Svetlana

AU - Khattab, Ayman

AU - Saavalainen, Päivi

AU - Meri, Seppo

AU - Kipar, Anja

AU - Sironen, Tarja

AU - Vapalahti, Olli

AU - Alitalo, Kari

AU - Ylä-Herttuala, Seppo

AU - Saksela, Kalle

PY - 2023/5/11

Y1 - 2023/5/11

KW - SARS-CoV-2

KW - COVID-19

KW - intranasal vaccination

KW - mucosal immunity

KW - adenoviral vector

KW - Mucosal immunity

KW - Covid-19

KW - Adenoviral vector

KW - Intranasal vaccination

KW - 3111 Biomedicine

KW - 11832 Microbiology and virology

U2 - 10.1016/j.vaccine.2023.04.020

DO - 10.1016/j.vaccine.2023.04.020

M3 - Article

VL - 41

SP - 3233

EP - 3246

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 20

ER -