Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease

Cornelis Blauwendraat, Hirotaka Iwaki, Mary B. Makarious, Sara Bandres-Ciga, Hampton L. Leonard, Francis P. Grenn, Julie Lake, Lynne Krohn, Manuela Tan, Jonggeol J. Kim, Jesse R. Gibbs, Dena G. Hernandez, Jennifer A. Ruskey, Lasse Pihlstrom, Mathias Toft, Jacobus J. van Hilten, Johan Marinus, Claudia Schulte, Kathrin Brockmann, Manu SharmaAri Siitonen, Kari Majamaa, Johanna Eerola-Rautio, Pentti J. Tienari, Donald G. Grosset, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Nick Wood, John Hardy, Ziv Gan-Or, Peter Heutink, Thomas C. Gasser, Huw R. Morris, Alastair J. Noyce, Mike A. Nalls, Andrew B. Singleton

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Objective: Parkinson's disease (PD) is a complex neurodegenerative disorder. Men are on average similar to 1.5 times more likely to develop PD compared to women with European ancestry. Over the years, genomewide association studies (GWAS) have identified numerous genetic risk factors for PD, however, it is unclear whether genetics contribute to disease etiology in a sex-specific manner.

Methods: In an effort to study sex-specific genetic factors associated with PD, we explored 2 large genetic datasets from the International Parkinson's Disease Genomics Consortium and the UK Biobank consisting of 13,020 male PD cases, 7,936 paternal proxy cases, 89,660 male controls, 7,947 female PD cases, 5,473 maternal proxy cases, and 90,662 female controls. We performed GWAS meta-analyses to identify distinct patterns of genetic risk contributing to disease in male versus female PD cases.

Results: In total, 19 genomewide significant regions were identified and no sex-specific effects were observed. A high genetic correlation between the male and female PD GWAS were identified (rg = 0.877) and heritability estimates were identical between male and female PD cases (similar to 20%).

Interpretation: We did not detect any significant genetic differences between male or female PD cases. Our study does not support the notion that common genetic variation on the autosomes could explain the difference in prevalence of PD between males and females cases at least when considering the current sample size under study. Further studies are warranted to investigate the genetic architecture of PD explained by X and Y chromosomes and further evaluate environmental effects that could potentially contribute to PD etiology in male versus female patients.

Originalspråkengelska
TidskriftAnnals of Neurology
Volym90
Utgåva1
Sidor (från-till)35-42
Antal sidor8
ISSN0364-5134
DOI
StatusPublicerad - juli 2021
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 3112 Neurovetenskaper
  • 3124 Neurologi och psykiatri

Citera det här