LACTB is a filament-forming protein localized in mitochondria

Zydrune Polianskyte-Prause, Nina Peitsaro, Arvydas Dapkunas, Julius Liobikas, Rabah Soliymani, Maciej Lalowski, Oliver Speer, Jani Seitsonen, Sarah Jane Butcher, Grazia M Cereghetti, Matts D Linder, Michael Merckel, James Thompson, Ove Eriksson-Rosenberg

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Sammanfattning

LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein. Penicillin-binding proteins are involved in the metabolism of peptidoglycan, the major bacterial cell wall constituent, implying that LACTB has been endowed with novel biochemical properties during eukaryote evolution. Here we demonstrate that LACTB is localized in the mitochondrial intermembrane space, where it is polymerized into stable filaments with a length extending more than a hundred nanometers. We infer that LACTB, through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization. These findings have implications for our understanding of mitochondrial evolution and function.
Originalspråkengelska
TidskriftProceedings of the National Academy of Sciences of the United States of America
Volym106
Utgåva45
Sidor (från-till)18960-18965
Antal sidor6
ISSN0027-8424
DOI
StatusPublicerad - 2009
MoE-publikationstypA1 Tidskriftsartikel-refererad

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