Left Ventricular speckle tracking echocardiography changes among early-stage breast cancer patients three years after radiotherapy

S.S. Tuohinen, T. Skytta, H. Huhtala, V. Virtanen, P.-L. Kellokumpu-Lehtinen, P. Raatikainen

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review


Background/Aim: Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. Materials and Methods: This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who were evaluated at baseline, immediately after RT and three years after RT. Sixty-one patients had left-sided (LSBC) and 20 right-sided breast cancer (RSBC). Results: Global longitudinal strain (GLS) declined from baseline –18.0±3.3% to –17.0±3.0% (p=0.015) at the three-year follow-up examination. A decline over 15% (GLS15) was observed in 19 (27%) patients. GLS15 was independently associated with aromatase inhibitor use (β=–1.977, p=0.001). In regional analysis, patients with LSBC had apical strain decline by 3.2±5.5% (p
TidskriftAnticancer Research
Sidor (från-till)4227-4236
Antal sidor10
StatusPublicerad - 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad


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