Long-range phase synchronization of highfrequency oscillations in human cortex

Gabriele Arnulfo, Sheng H. Wang, Vladislav Myrov, Benedetta Toselli, Jonni Hirvonen, MM Fato, L Nobili, F Cardinale, A Rubino, Alexander Zhigalov, Satu Palva, Matias Palva

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

Inter-areal synchronization of neuronal oscillations at frequencies below similar to 100Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100-400Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.

Originalspråkengelska
Artikelnummer5363
TidskriftNature Communications
Volym11
Nummer1
Antal sidor15
ISSN2041-1723
DOI
StatusPublicerad - 23 okt. 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

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  • 3112 Neurovetenskaper

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