Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes; Maximillian Hafer; Joni Vuorio; Julie A. Tucker; Hauke Winkelmann; Sara Loechte; Tess A. Stanly; Katiuska D. Pulgar Prieto; Chetan Poojari; Vivek Sharma; Christian P. Richter; Rainer Kurre; Stevan R. Hubbard; K. Christopher Garcia; Ignacio Moraga; Ilpo Vattulainen; Ian S. Hitchcock; Jacob Piehler

doi:10.1126/science.aaw3242

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A. Tucker, Hauke Winkelmann, Sara Loechte, Tess A. Stanly, Katiuska D. Pulgar Prieto, Chetan Poojari, Vivek Sharma, Christian P. Richter, Rainer Kurre, Stevan R. Hubbard, K. Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S. Hitchcock, Jacob Piehler

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Science
Volym	367
Utgåva	6478
Sidor (från-till)	643-+
Antal sidor	58
ISSN	0036-8075
DOI	https://doi.org/10.1126/science.aaw3242
Status	Publicerad - 7 feb 2020
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

114 Fysik
221 Nanoteknologi

Åtkomst av dokument

10.1126/science.aaw3242

Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases
Sharma, V., Djurabekova, A., Haapanen, O., Malkamäki, A., Lasham, J., Reidelbach, M., Chiarini, V. & Nyman, A. I.
Projekt: Helsingfors Universitetets treåriga forskningsprojekt

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Wilmes, S., Hafer, M., Vuorio, J., Tucker, J. A., Winkelmann, H., Loechte, S., Stanly, T. A., Prieto, K. D. P., Poojari, C., Sharma, V., Richter, C. P., Kurre, R., Hubbard, S. R., Garcia, K. C., Moraga, I., Vattulainen, I., Hitchcock, I. S., & Piehler, J. (2020). Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science, 367(6478), 643-+. https://doi.org/10.1126/science.aaw3242

Wilmes, Stephan ; Hafer, Maximillian ; Vuorio, Joni ; Tucker, Julie A. ; Winkelmann, Hauke ; Loechte, Sara ; Stanly, Tess A. ; Prieto, Katiuska D. Pulgar ; Poojari, Chetan ; Sharma, Vivek ; Richter, Christian P. ; Kurre, Rainer ; Hubbard, Stevan R. ; Garcia, K. Christopher ; Moraga, Ignacio ; Vattulainen, Ilpo ; Hitchcock, Ian S. ; Piehler, Jacob. / Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. I: Science. 2020 ; Vol. 367, Nr. 6478. s. 643-+.

@article{8751ce0bb9df41c794a076416242ffed,

title = "Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations",

keywords = "GROWTH-HORMONE RECEPTOR, THROMBOPOIETIN RECEPTOR, ERYTHROPOIETIN RECEPTOR, CONSTITUTIVE ACTIVATION, PSEUDOKINASE-DOMAIN, STRUCTURAL BASIS, DIMERIZATION, DYNAMICS, LIGAND, JAK2, 114 Physical sciences, 221 Nano-technology",

author = "Stephan Wilmes and Maximillian Hafer and Joni Vuorio and Tucker, {Julie A.} and Hauke Winkelmann and Sara Loechte and Stanly, {Tess A.} and Prieto, {Katiuska D. Pulgar} and Chetan Poojari and Vivek Sharma and Richter, {Christian P.} and Rainer Kurre and Hubbard, {Stevan R.} and Garcia, {K. Christopher} and Ignacio Moraga and Ilpo Vattulainen and Hitchcock, {Ian S.} and Jacob Piehler",

year = "2020",

month = feb,

day = "7",

doi = "10.1126/science.aaw3242",

language = "English",

volume = "367",

pages = "643--+",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science (AAAS)",

number = "6478",

}

Wilmes, S, Hafer, M, Vuorio, J, Tucker, JA, Winkelmann, H, Loechte, S, Stanly, TA, Prieto, KDP, Poojari, C , Sharma, V, Richter, CP, Kurre, R, Hubbard, SR, Garcia, KC, Moraga, I, Vattulainen, I, Hitchcock, IS & Piehler, J 2020, 'Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations', Science, vol. 367, nr. 6478, s. 643-+. https://doi.org/10.1126/science.aaw3242

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. / Wilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A.; Winkelmann, Hauke; Loechte, Sara; Stanly, Tess A.; Prieto, Katiuska D. Pulgar; Poojari, Chetan ; Sharma, Vivek; Richter, Christian P.; Kurre, Rainer; Hubbard, Stevan R.; Garcia, K. Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S.; Piehler, Jacob.

I: Science, Vol. 367, Nr. 6478, 07.02.2020, s. 643-+.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

AU - Wilmes, Stephan

AU - Hafer, Maximillian

AU - Vuorio, Joni

AU - Tucker, Julie A.

AU - Winkelmann, Hauke

AU - Loechte, Sara

AU - Stanly, Tess A.

AU - Prieto, Katiuska D. Pulgar

AU - Poojari, Chetan

AU - Sharma, Vivek

AU - Richter, Christian P.

AU - Kurre, Rainer

AU - Hubbard, Stevan R.

AU - Garcia, K. Christopher

AU - Moraga, Ignacio

AU - Vattulainen, Ilpo

AU - Hitchcock, Ian S.

AU - Piehler, Jacob

PY - 2020/2/7

Y1 - 2020/2/7

KW - GROWTH-HORMONE RECEPTOR

KW - THROMBOPOIETIN RECEPTOR

KW - ERYTHROPOIETIN RECEPTOR

KW - CONSTITUTIVE ACTIVATION

KW - PSEUDOKINASE-DOMAIN

KW - STRUCTURAL BASIS

KW - DIMERIZATION

KW - DYNAMICS

KW - LIGAND

KW - JAK2

KW - 114 Physical sciences

KW - 221 Nano-technology

U2 - 10.1126/science.aaw3242

DO - 10.1126/science.aaw3242

M3 - Article

VL - 367

SP - 643-+

JO - Science

JF - Science

SN - 0036-8075

IS - 6478

ER -

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Vetenskapsgrenar

Åtkomst av dokument

Projekt

Molecular mechanisms of mitochondrial enzymes, and their role in health and diseases

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