Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations

Mohammad Mahmoudzadeh; Aniket Magarkar; Artturi Koivuniemi; Tomasz Róg; Alex Bunker

doi:10.1021/acs.molpharmaceut.1c00122

Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations

Mohammad Mahmoudzadeh, Aniket Magarkar, Artturi Koivuniemi, Tomasz Róg, Alex Bunker

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Molecular Pharmaceutics
Volym	18
Nummer	7
Sidor (från-till)	2612-2621
Antal sidor	10
ISSN	1543-8384
DOI	https://doi.org/10.1021/acs.molpharmaceut.1c00122
Status	Publicerad - 5 juli 2021
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

317 Farmaci

Åtkomst av dokument

10.1021/acs.molpharmaceut.1c00122

Mahmoudzadeh_et_al_manuscriptAccepterat manuskript från författare, 2,15 MB
acs.molpharmaceut.1c00122Slutlig publicerad version, 2,59 MBLicens: CC BY

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title = "Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations",

keywords = "ATOM FORCE-FIELD, DRUG-DELIVERY, EFFECTIVE INCLUSION, HEXAGONAL PHASE, INDUCED DESTABILIZATION, LIPID-BILAYERS, PARTICLE MESH EWALD, PEGylated pH-sensitive liposomes, PHASE-TRANSITION, POTENTIAL FUNCTIONS, TRIGGERED RELEASE, bilayer hydrophilicity, cholesteryl hemisuccinate, molecular dynamics simulations, phase transition, 317 Pharmacy",

author = "Mohammad Mahmoudzadeh and Aniket Magarkar and Artturi Koivuniemi and Tomasz R{\'o}g and Alex Bunker",

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AU - Mahmoudzadeh, Mohammad

AU - Magarkar, Aniket

AU - Koivuniemi, Artturi

AU - Róg, Tomasz

AU - Bunker, Alex

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KW - PARTICLE MESH EWALD

KW - PEGylated pH-sensitive liposomes

KW - PHASE-TRANSITION

KW - POTENTIAL FUNCTIONS

KW - TRIGGERED RELEASE

KW - bilayer hydrophilicity

KW - cholesteryl hemisuccinate

KW - molecular dynamics simulations

KW - phase transition

KW - 317 Pharmacy

U2 - 10.1021/acs.molpharmaceut.1c00122

DO - 10.1021/acs.molpharmaceut.1c00122

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JF - Molecular Pharmaceutics

SN - 1543-8384

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