Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

Laura Giorgi; Akseli Niemelä; Esa-Pekka Kumpula; Ossi Natri; Petteri Parkkila; Juha T. Huiskonen; Artturi Koivuniemi

doi:10.1021/acs.molpharmaceut.2c00540

Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

Laura Giorgi, Akseli Niemelä, Esa-Pekka Kumpula, Ossi Natri, Petteri Parkkila, Juha T. Huiskonen, Artturi Koivuniemi

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Molecular Pharmaceutics
Volym	19
Nummer	11
Sidor (från-till)	4135-4148
Antal sidor	14
ISSN	1543-8384
DOI	https://doi.org/10.1021/acs.molpharmaceut.2c00540
Status	Publicerad - 7 nov. 2022
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

317 Farmaci

Åtkomst av dokument

10.1021/acs.molpharmaceut.2c00540Licens: CC BY

acs.molpharmaceut.2c00540Slutlig publicerad version, 9,31 MBLicens: CC BY

Citera det här

Giorgi, L., Niemelä, A., Kumpula, E.-P., Natri, O., Parkkila, P., Huiskonen, J. T., & Koivuniemi, A. (2022). Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids. Molecular Pharmaceutics, 19(11), 4135-4148. https://doi.org/10.1021/acs.molpharmaceut.2c00540

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title = "Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids",

keywords = "acyltransferase, reverse cholesterol transport, apolipoprotein mimetics, high-density lipoprotein (HDL), molecular dynamics simulation, electron microscopy imaging, HIGH-DENSITY-LIPOPROTEINS, LECITHINCHOLESTEROL ACYLTRANSFERASE, DISCOIDAL COMPLEXES, TRANSITIONS, DOMAIN, SIZE, 317 Pharmacy",

author = "Laura Giorgi and Akseli Niemel{\"a} and Esa-Pekka Kumpula and Ossi Natri and Petteri Parkkila and Huiskonen, {Juha T.} and Artturi Koivuniemi",

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month = nov,

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doi = "10.1021/acs.molpharmaceut.2c00540",

language = "English",

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journal = "Molecular Pharmaceutics",

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Giorgi, L , Niemelä, A , Kumpula, E-P, Natri, O, Parkkila, P, Huiskonen, JT & Koivuniemi, A 2022, 'Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids', Molecular Pharmaceutics, vol. 19, nr. 11, s. 4135-4148. https://doi.org/10.1021/acs.molpharmaceut.2c00540

Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids. / Giorgi, Laura ; Niemelä, Akseli ; Kumpula, Esa-Pekka et al.
I: Molecular Pharmaceutics, Vol. 19, Nr. 11, 07.11.2022, s. 4135-4148.

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

TY - JOUR

T1 - Mechanistic Insights into the Activation of Lecithin-Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

AU - Giorgi, Laura

AU - Niemelä, Akseli

AU - Kumpula, Esa-Pekka

AU - Natri, Ossi

AU - Parkkila, Petteri

AU - Huiskonen, Juha T.

AU - Koivuniemi, Artturi

PY - 2022/11/7

Y1 - 2022/11/7

KW - acyltransferase

KW - reverse cholesterol transport

KW - apolipoprotein mimetics

KW - high-density lipoprotein (HDL)

KW - molecular dynamics simulation

KW - electron microscopy imaging

KW - HIGH-DENSITY-LIPOPROTEINS

KW - LECITHINCHOLESTEROL ACYLTRANSFERASE

KW - DISCOIDAL COMPLEXES

KW - TRANSITIONS

KW - DOMAIN

KW - SIZE

KW - 317 Pharmacy

U2 - 10.1021/acs.molpharmaceut.2c00540

DO - 10.1021/acs.molpharmaceut.2c00540

M3 - Article

SN - 1543-8384

VL - 19

SP - 4135

EP - 4148

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 11

ER -