Method for preparation of betulinic acid from betulin (SE 2011050820)

Niko Wickholm, Sami Alakurtti, Jari Yli-Kauhaluoma, Salme Koskimies

Forskningsoutput: PatentVetenskaplig

Sammanfattning

The present invention relates to a method for prepn. of betulinic acid (I) from betulin (II). The method comprises oxidizing II to I with a catalyst III [R1 = H; R2 = H, 2-chloroacetamido, 2-bromoacetamido, 2-iodoacetamido, cyano, maleimido, methoxy, amino, carboxy, acetamido, hydroxy; R1R2 = O], e.g. 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), in the presence of a hypervalent iodine reagent as oxidant.
Originalspråksvenska
Utgivningsår13 mar 2013
StatusPublicerad - 13 mar 2013
MoE-publikationstypH1 Beviljat patent

Citera det här

Wickholm, N., Alakurtti, S., Yli-Kauhaluoma, J., & Koskimies, S. (2013). Method for preparation of betulinic acid from betulin (SE 2011050820). (Patentnr. SE 2011050820).
Wickholm, Niko (Författare) ; Alakurtti, Sami (Författare) ; Yli-Kauhaluoma, Jari (Författare) ; Koskimies, Salme (Författare). / Method for preparation of betulinic acid from betulin (SE 2011050820). Patentnr.: SE 2011050820. mar 13, 2013.
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abstract = "The present invention relates to a method for prepn. of betulinic acid (I) from betulin (II). The method comprises oxidizing II to I with a catalyst III [R1 = H; R2 = H, 2-chloroacetamido, 2-bromoacetamido, 2-iodoacetamido, cyano, maleimido, methoxy, amino, carboxy, acetamido, hydroxy; R1R2 = O], e.g. 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), in the presence of a hypervalent iodine reagent as oxidant.",
author = "Niko Wickholm and Sami Alakurtti and Jari Yli-Kauhaluoma and Salme Koskimies",
year = "2013",
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Wickholm, N, Alakurtti, S, Yli-Kauhaluoma, J & Koskimies, S mar. 13 2013, Method for preparation of betulinic acid from betulin (SE 2011050820), Patentnr. SE 2011050820.

Method for preparation of betulinic acid from betulin (SE 2011050820). / Wickholm, Niko; Alakurtti, Sami; Yli-Kauhaluoma, Jari; Koskimies, Salme.

Patentnr.: SE 2011050820. mar 13, 2013.

Forskningsoutput: PatentVetenskaplig

TY - PAT

T1 - Method for preparation of betulinic acid from betulin (SE 2011050820)

AU - Wickholm, Niko

AU - Alakurtti, Sami

AU - Yli-Kauhaluoma, Jari

AU - Koskimies, Salme

PY - 2013/3/13

Y1 - 2013/3/13

N2 - The present invention relates to a method for prepn. of betulinic acid (I) from betulin (II). The method comprises oxidizing II to I with a catalyst III [R1 = H; R2 = H, 2-chloroacetamido, 2-bromoacetamido, 2-iodoacetamido, cyano, maleimido, methoxy, amino, carboxy, acetamido, hydroxy; R1R2 = O], e.g. 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), in the presence of a hypervalent iodine reagent as oxidant.

AB - The present invention relates to a method for prepn. of betulinic acid (I) from betulin (II). The method comprises oxidizing II to I with a catalyst III [R1 = H; R2 = H, 2-chloroacetamido, 2-bromoacetamido, 2-iodoacetamido, cyano, maleimido, methoxy, amino, carboxy, acetamido, hydroxy; R1R2 = O], e.g. 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), in the presence of a hypervalent iodine reagent as oxidant.

M3 - Patent

M1 - SE 2011050820

Y2 - 2013/03/13

ER -

Wickholm N, Alakurtti S, Yli-Kauhaluoma J, Koskimies S. Method for preparation of betulinic acid from betulin (SE 2011050820). SE 2011050820. 2013 mar 13.