Microfluidic analysis techniques for safety assessment of pharmaceutical nano- and microsystems

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This chapter reviews the evolution of microfabrication methods and materials, applicable to manufacturing of micro total analysis systems (or lab‐on‐a‐chip), from a general perspective. It discusses the possibilities and limitations associated with microfluidic cell culturing, or so called organ‐on‐a‐chip technology, together with selected examples of their exploitation to characterization of pharmaceutical nano‐ and microsystems. Materials selection plays a pivotal role in terms of ensuring the cell adhesion and viability as well as defining the prevailing culture conditions inside the microfluidic channels. The chapter focuses on the hepatic safety assessment of nanoparticles and gives an overview of the development of microfluidic immobilized enzyme reactors that could facilitate examination of the hepatic effects of nanomedicines under physiologically relevant conditions. It also provides an overview of the future prospects regarding system‐level integration possibilities facilitated by microfabrication of miniaturized separation and sample preparation systems as integral parts of microfluidic in vitro models.
Titel på värdpublikationCharacterization of Pharmaceutical Nano- and Microsystems
RedaktörerLeena Peltonen
Antal sidor38
FörlagJohn Wiley & Sons Ltd.
Utgivningsdatum19 jan. 2021
ISBN (tryckt)9781119414049
ISBN (elektroniskt)9781119414018
StatusPublicerad - 19 jan. 2021
MoE-publikationstypA3 Del av bok eller annan forskningsbok


NamnAdvances in Pharmaceutical Technology
FörlagJohn Wiley & Sons, Ltd.


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  • 221 Nanoteknologi

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