Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems

Yuezhou Zhang, Dongfei Liu, Hongbo Zhang, Helder Almeida Santos

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

Sammanfattning

Nanotechnology-based therapeutics, operating at scales of billionths of a meter, hold great potentials in altering the methods and efficiency of drug delivery. However, a major bottleneck in the application of nanoparticulate drug delivery systems is their slow translation to the industrial practice, attributed to the quality control and inadequate productivity of the conventional preparing methods. In contrast, microfluidics fabricates nanoparticles in a well-tailored, reproducible, and high-throughput manner, therefore hold great potentials to address the barrier to translate laboratory nanomedicine formulations to industrial applications. This chapter overviews the microfluidic devices developed to prepare nanoparticulate drug delivery systems, covering Y- and T-shaped mixing, digital microfluidic droplet generator, hydrodynamic flow focusing, confined impinging jets mixer, multiinlet vortex mixer, and gas-liquid segmented microfluidics. Altogether, the microfluidic technique offers a promising alternative to industrialize nanoparticulate drug delivery systems.
Originalspråkengelska
Titel på gästpublikationMicrofluidics for Pharmaceutical Applications : From Nano/Micro Systems Fabrication to Controlled Drug Delivery
RedaktörerHelder A. Santos, Dongfei Liu, Hongbo Zhang
Antal sidor23
UtgivningsortSan Diego
FörlagElsevier
Utgivningsdatum2019
Utgåva1st
Sidor155-177
ISBN (tryckt)978-0-12-812659-2
ISBN (elektroniskt)978-0-12-812660-8
DOI
StatusPublicerad - 2019
MoE-publikationstypA3 Del av bok eller annan forskningsbok

Publikationsserier

NamnMicro and Nano Technologies

Vetenskapsgrenar

  • 221 Nanoteknologi
  • 317 Farmaci

Citera det här

Zhang, Y., Liu, D., Zhang, H., & Almeida Santos, H. (2019). Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. I H. A. Santos, D. Liu, & H. Zhang (Red.), Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery (1st red., s. 155-177). (Micro and Nano Technologies). San Diego: Elsevier. https://doi.org/10.1016/B978-0-12-812659-2.00007-7
Zhang, Yuezhou ; Liu, Dongfei ; Zhang, Hongbo ; Almeida Santos, Helder. / Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. redaktör / Helder A. Santos ; Dongfei Liu ; Hongbo Zhang. 1st. red. San Diego : Elsevier, 2019. s. 155-177 (Micro and Nano Technologies).
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abstract = "Nanotechnology-based therapeutics, operating at scales of billionths of a meter, hold great potentials in altering the methods and efficiency of drug delivery. However, a major bottleneck in the application of nanoparticulate drug delivery systems is their slow translation to the industrial practice, attributed to the quality control and inadequate productivity of the conventional preparing methods. In contrast, microfluidics fabricates nanoparticles in a well-tailored, reproducible, and high-throughput manner, therefore hold great potentials to address the barrier to translate laboratory nanomedicine formulations to industrial applications. This chapter overviews the microfluidic devices developed to prepare nanoparticulate drug delivery systems, covering Y- and T-shaped mixing, digital microfluidic droplet generator, hydrodynamic flow focusing, confined impinging jets mixer, multiinlet vortex mixer, and gas-liquid segmented microfluidics. Altogether, the microfluidic technique offers a promising alternative to industrialize nanoparticulate drug delivery systems.",
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Zhang, Y, Liu, D, Zhang, H & Almeida Santos, H 2019, Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. i HA Santos, D Liu & H Zhang (red), Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. 1st uppl, Micro and Nano Technologies, Elsevier, San Diego, s. 155-177. https://doi.org/10.1016/B978-0-12-812659-2.00007-7

Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. / Zhang, Yuezhou; Liu, Dongfei; Zhang, Hongbo; Almeida Santos, Helder.

Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. red. / Helder A. Santos; Dongfei Liu; Hongbo Zhang. 1st. red. San Diego : Elsevier, 2019. s. 155-177 (Micro and Nano Technologies).

Forskningsoutput: Kapitel i bok/rapport/konferenshandlingKapitelVetenskapligPeer review

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AB - Nanotechnology-based therapeutics, operating at scales of billionths of a meter, hold great potentials in altering the methods and efficiency of drug delivery. However, a major bottleneck in the application of nanoparticulate drug delivery systems is their slow translation to the industrial practice, attributed to the quality control and inadequate productivity of the conventional preparing methods. In contrast, microfluidics fabricates nanoparticles in a well-tailored, reproducible, and high-throughput manner, therefore hold great potentials to address the barrier to translate laboratory nanomedicine formulations to industrial applications. This chapter overviews the microfluidic devices developed to prepare nanoparticulate drug delivery systems, covering Y- and T-shaped mixing, digital microfluidic droplet generator, hydrodynamic flow focusing, confined impinging jets mixer, multiinlet vortex mixer, and gas-liquid segmented microfluidics. Altogether, the microfluidic technique offers a promising alternative to industrialize nanoparticulate drug delivery systems.

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Zhang Y, Liu D, Zhang H, Almeida Santos H. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems. I Santos HA, Liu D, Zhang H, redaktörer, Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery. 1st red. San Diego: Elsevier. 2019. s. 155-177. (Micro and Nano Technologies). https://doi.org/10.1016/B978-0-12-812659-2.00007-7