TY - PAT
T1 - Modified VEGF-A with improved angiogenic properties
AU - Alitalo, Kari Kustaa
AU - Tammela, Tuomas Leo Herman
AU - Keskitalo, Salla Elina
AU - Pajusola, Katri Marianna
AU - Jeltsch, Markku Michael
AU - Ylä-Herttuala, Seppo
AU - Kärpänen, Terhi Hannele
AU - Eriksson, Ulf
AU - Uutela, Marko Juha Tapani
PY - 2011/9/27
Y1 - 2011/9/27
N2 - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
AB - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.
M3 - Patent
M1 - US 8,025,886 B2
Y2 - 2011/09/27
PB - US Patent and Trademark Office
ER -