Modified VEGF-A with improved angiogenic properties

Kari Kustaa Alitalo; Tuomas Leo Herman Tammela; Salla Elina Keskitalo; Katri Marianna Pajusola; Markku Michael Jeltsch; Seppo Ylä-Herttuala; Terhi Hannele Kärpänen; Ulf Eriksson; Marko Juha Tapani Uutela

Modified VEGF-A with improved angiogenic properties

Kari Kustaa Alitalo, Tuomas Leo Herman Tammela, Salla Elina Keskitalo, Katri Marianna Pajusola, Markku Michael Jeltsch, Seppo Ylä-Herttuala, Terhi Hannele Kärpänen, Ulf Eriksson, Marko Juha Tapani Uutela

Forskningsoutput: Patent

Sammanfattning

The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

Originalspråk	engelska
Utgivningsår	27 sep 2011
Status	Publicerad - 27 sep 2011
MoE-publikationstyp	H1 Beviljat patent

Åtkomst av dokument

Modified VEGF-A with improved angiogenic properties

http://patft1.uspto.gov/netacgi/nph-Parser?patentnumber=8025886

Citera det här

Alitalo, Kari Kustaa (Författare) ; Tammela, Tuomas Leo Herman (Författare) ; Keskitalo, Salla Elina (Författare) ; Pajusola, Katri Marianna (Författare) ; Jeltsch, Markku Michael (Författare) ; Ylä-Herttuala, Seppo (Författare) ; Kärpänen, Terhi Hannele (Författare) ; Eriksson, Ulf (Författare) ; Uutela, Marko Juha Tapani (Författare). / Modified VEGF-A with improved angiogenic properties. US Patent and Trademark Office. Patentnr.: US 8,025,886 B2. sep 27, 2011.

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title = "Modified VEGF-A with improved angiogenic properties",

abstract = "The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.",

author = "Alitalo, {Kari Kustaa} and Tammela, {Tuomas Leo Herman} and Keskitalo, {Salla Elina} and Pajusola, {Katri Marianna} and Jeltsch, {Markku Michael} and Seppo Yl{\"a}-Herttuala and K{\"a}rp{\"a}nen, {Terhi Hannele} and Ulf Eriksson and Uutela, {Marko Juha Tapani}",

year = "2011",

month = sep,

day = "27",

language = "English",

publisher = "US Patent and Trademark Office",

address = "United States",

type = "Patent",

note = "US 8,025,886 B2",

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TY - PAT

T1 - Modified VEGF-A with improved angiogenic properties

AU - Alitalo, Kari Kustaa

AU - Tammela, Tuomas Leo Herman

AU - Keskitalo, Salla Elina

AU - Pajusola, Katri Marianna

AU - Jeltsch, Markku Michael

AU - Ylä-Herttuala, Seppo

AU - Kärpänen, Terhi Hannele

AU - Eriksson, Ulf

AU - Uutela, Marko Juha Tapani

PY - 2011/9/27

Y1 - 2011/9/27

N2 - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

AB - The present invention is directed to methods and compositions for making and using chimeric polypeptides that comprise a VEGFR-2 ligand. The chimeric molecules of the present invention retain VEGFR-2 binding activity and an enhanced angiogenic activity as compared to native VEGF-A.

M3 - Patent

M1 - US 8,025,886 B2

Y2 - 2011/09/27

PB - US Patent and Trademark Office

ER -