Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up

Juuso Jalasto; Ritva Luukkonen; Ari Lindqvist; Arnulf Langhammer; Hannu Kankaanranta; Helena Backman; Eva Rönmark; Anssi Sovijärvi; Paula Kauppi; Päivi Piirilä

doi:10.1097/JOM.0000000000002718

Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up

Juuso Jalasto, Ritva Luukkonen, Ari Lindqvist, Arnulf Langhammer, Hannu Kankaanranta, Helena Backman, Eva Rönmark, Anssi Sovijärvi, Paula Kauppi, Päivi Piirilä

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Sammanfattning

Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.

Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.

Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).

Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

Originalspråk	engelska
Tidskrift	Journal of Occupational and Environmental Medicine
Volym	65
Nummer	1
Sidor (från-till)	22-28
Antal sidor	7
ISSN	1076-2752
DOI	https://doi.org/10.1097/JOM.0000000000002718
Status	Publicerad - 1 jan. 2023
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3121 Allmänmedicin, inre medicin och annan klinisk medicin

Åtkomst av dokument

10.1097/JOM.0000000000002718Licens: CC BY

Mortality_Associated_With_Occupational_Exposure_in.4Slutlig publicerad version, 298 KBLicens: CC BY-NC-ND

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title = "Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up",

abstract = "Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality",

keywords = "3121 General medicine, internal medicine and other clinical medicine, Asthma, COPD, Occupational Exposure, Mortality, Copd, Finland, Airborne occupational exposure, Asthma, Causes of death, Chronic lower airway disease, General population cohort, Job-exposure matrix, Postal questionnaire, Prospective study",

author = "Juuso Jalasto and Ritva Luukkonen and Ari Lindqvist and Arnulf Langhammer and Hannu Kankaanranta and Helena Backman and Eva R{\"o}nmark and Anssi Sovij{\"a}rvi and Paula Kauppi and P{\"a}ivi Piiril{\"a}",

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T1 - Mortality associated with occupational exposure in Helsinki, Finland - a 24-year follow-up

AU - Jalasto, Juuso

AU - Luukkonen, Ritva

AU - Lindqvist, Ari

AU - Langhammer, Arnulf

AU - Kankaanranta, Hannu

AU - Backman, Helena

AU - Rönmark, Eva

AU - Sovijärvi, Anssi

AU - Kauppi, Paula

AU - Piirilä, Päivi

PY - 2023/1/1

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N2 - Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

AB - Objectives: Our objective was to study mortality related to different obstructive lung diseases, occupational exposure, and their potential joint effect in a large, randomized population-based cohort.Methods: We divided the participants based on the answers to asthma and COPD diagnoses and occupational exposure and used a combined effects model and compared the results to no asthma or COPD with no occupational exposure.Results: High exposure had a hazard ratio (HR) 1.34 (1.11-1.62) and asthma and COPD coexistence 1.58 (1.10-2.27). The combined effects of intermediate exposure and coexistence had a HR 2.20 (1.18-4.09), high exposure with co-existence 1.94 (1.10-3.42) for overall mortality and sub-hazard ratio for respiratory related mortality sHR 3.21 (1.87-5.50).Conclusions: High occupational exposure increased overall, but not respiratory related mortality hazard while co-existing asthma and COPD overall and respiratory related hazard of mortality

KW - 3121 General medicine, internal medicine and other clinical medicine

KW - Asthma

KW - COPD

KW - Occupational Exposure

KW - Mortality

KW - Copd

KW - Finland

KW - Airborne occupational exposure

KW - Asthma

KW - Causes of death

KW - Chronic lower airway disease

KW - General population cohort

KW - Job-exposure matrix

KW - Postal questionnaire

KW - Prospective study

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DO - 10.1097/JOM.0000000000002718

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