Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections

Mina Zare, Mohamad Zare, Jonathan A. Butler, Seeram Ramakrishna

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Sammanfattning

One of the major complications associated with the implantation of biomedical devices regardless of their function is biomaterial-associated infection. Infections are generally initiated by opportunistic bacterial colonization and biofilm development on the surface of implanted biomaterials, rendering the infection impervious to host defenses and antimicrobials. Moreover, the infection around soft tissues also has a significant role in biomaterial-associated infections. It is well-documented that the nature of an implant infection is influenced by the design and composition of the implant biomaterial, host environment, clinical procedure, and patient hygiene. Herein, we explore the adhesion mechanisms of bacteria to the biomaterials and review systematic antimicrobial strategies to reduce the contamination of biomaterials and underlying implant infection using Staphylococcus aureus as a model bacterial pathogen. Also, we discuss the preventive and therapeutic strategies and explain the future perspectives for the development of nanoscience-based strategies for the engineering of antimicrobial surfaces, including the nanostructure surface, microbe-surface interactions, synthetic nanostructured surfaces, dynamic surfaces with antifouling agents, and coated surfaces with antimicrobial properties (polymer coating, surface release active coating).

Originalspråkengelska
TidskriftAcs applied nano materials
Volym4
Nummer5
Sidor (från-till)4269-4283
Antal sidor15
ISSN2574-0970
DOI
StatusPublicerad - 28 maj 2021
Externt publiceradJa
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

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© 2021 American Chemical Society.

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  • 221 Nanoteknologi

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