Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency

Jiachen Li, Weiwei Zhang, Yan Gao, Haibei Tong, Zhenyu Chen, Jisen Shi, Hélder A. Santos, Bing Xia

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

Sammanfattning

The development of drug delivery systems based on external stimuli-responsive nanocarriers is important to overcome multidrug resistance of breast cancer cells. Herein, iron oxide/gold (Fe3O4/Au) nanoparticles were first fabricated via a simple hydrothermal reaction, and subsequently loaded into porous silicon nanoparticles (PSiNPs) via electrostatic interactions to construct PSiNPs@(Fe3O4/Au) nanocomposites. As-prepared PSiNPs@(Fe3O4/Au) nanocomposites exhibited excellent super-paramagnetism, photothermal effect, and T2-weight magnetic resonance imaging capability. Particularly, with the help of magnetic field, the cellular uptake of PSiNPs@(Fe3O4/Au) nanocomposites was significantly enhanced in drug-resistant breast cancer cells. Moreover, PSiNPs@(Fe3O4/Au) nanocomposites as carriers showed a high loading and NIR light-triggered release of anticancer drug. Based on the synergistic effect of magnetic field-enhanced cellular uptake and NIR light-triggered intracellular release, the amount of anticancer drug carried by PSiNPs@(Fe3O4/Au) nanocarriers into the nuclei of drug-resistant breast cancer cells sharply increased, accompanied with improved chemo-photothermal therapeutic efficacy. Finally, PSiNPs@(Fe3O4/Au) nanocomposites under the combination conditions of magnetic field attraction and NIR light irradiation also showed improved anticancer drug penetration and accumulation in three-dimensional multicellular spheroids composed of drug-resistant breast cancer cells, leading to better growth inhibition effect. Overall, the fabricated PSiNPs@(Fe3O4/Au) nanocomposites demonstrated great potential for the therapy of multidrug-resistant breast cancer in future.
Originalspråkengelska
TidskriftJournal of Materials Chemistry. B
Volym8
Utgåva3
Sidor (från-till)546-557
Antal sidor12
ISSN2050-750X
DOI
StatusPublicerad - 2020
MoE-publikationstypA1 Tidskriftsartikel-refererad

Vetenskapsgrenar

  • 317 Farmaci
  • 221 Nanoteknologi

Citera det här

@article{1d4fcc4df7c942388517e1127515576e,
title = "Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency",
abstract = "The development of drug delivery systems based on external stimuli-responsive nanocarriers is important to overcome multidrug resistance of breast cancer cells. Herein, iron oxide/gold (Fe3O4/Au) nanoparticles were first fabricated via a simple hydrothermal reaction, and subsequently loaded into porous silicon nanoparticles (PSiNPs) via electrostatic interactions to construct PSiNPs@(Fe3O4/Au) nanocomposites. As-prepared PSiNPs@(Fe3O4/Au) nanocomposites exhibited excellent super-paramagnetism, photothermal effect, and T2-weight magnetic resonance imaging capability. Particularly, with the help of magnetic field, the cellular uptake of PSiNPs@(Fe3O4/Au) nanocomposites was significantly enhanced in drug-resistant breast cancer cells. Moreover, PSiNPs@(Fe3O4/Au) nanocomposites as carriers showed a high loading and NIR light-triggered release of anticancer drug. Based on the synergistic effect of magnetic field-enhanced cellular uptake and NIR light-triggered intracellular release, the amount of anticancer drug carried by PSiNPs@(Fe3O4/Au) nanocarriers into the nuclei of drug-resistant breast cancer cells sharply increased, accompanied with improved chemo-photothermal therapeutic efficacy. Finally, PSiNPs@(Fe3O4/Au) nanocomposites under the combination conditions of magnetic field attraction and NIR light irradiation also showed improved anticancer drug penetration and accumulation in three-dimensional multicellular spheroids composed of drug-resistant breast cancer cells, leading to better growth inhibition effect. Overall, the fabricated PSiNPs@(Fe3O4/Au) nanocomposites demonstrated great potential for the therapy of multidrug-resistant breast cancer in future.",
keywords = "317 Pharmacy, 221 Nano-technology, ANTICANCER DRUGS, TARGETED-THERAPY, DELIVERY-SYSTEMS, NANOPARTICLES, DOXORUBICIN, NANOCOMPOSITES, NANOMEDICINES, PLATFORM",
author = "Jiachen Li and Weiwei Zhang and Yan Gao and Haibei Tong and Zhenyu Chen and Jisen Shi and Santos, {H{\'e}lder A.} and Bing Xia",
year = "2020",
doi = "10.1039/C9TB02340B",
language = "English",
volume = "8",
pages = "546--557",
journal = "Journal of Materials Chemistry. B",
issn = "2050-750X",
publisher = "Royal Society of Chemistry",
number = "3",

}

Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency. / Li, Jiachen; Zhang, Weiwei; Gao, Yan ; Tong, Haibei ; Chen, Zhenyu ; Shi, Jisen ; Santos, Hélder A.; Xia, Bing.

I: Journal of Materials Chemistry. B, Vol. 8, Nr. 3, 2020, s. 546-557.

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

TY - JOUR

T1 - Near-infrared light and magnetic field dual-responsive porous silicon-based nanocarriers to overcome multidrug resistance of breast cancer cells with enhanced efficiency

AU - Li, Jiachen

AU - Zhang, Weiwei

AU - Gao, Yan

AU - Tong, Haibei

AU - Chen, Zhenyu

AU - Shi, Jisen

AU - Santos, Hélder A.

AU - Xia, Bing

PY - 2020

Y1 - 2020

N2 - The development of drug delivery systems based on external stimuli-responsive nanocarriers is important to overcome multidrug resistance of breast cancer cells. Herein, iron oxide/gold (Fe3O4/Au) nanoparticles were first fabricated via a simple hydrothermal reaction, and subsequently loaded into porous silicon nanoparticles (PSiNPs) via electrostatic interactions to construct PSiNPs@(Fe3O4/Au) nanocomposites. As-prepared PSiNPs@(Fe3O4/Au) nanocomposites exhibited excellent super-paramagnetism, photothermal effect, and T2-weight magnetic resonance imaging capability. Particularly, with the help of magnetic field, the cellular uptake of PSiNPs@(Fe3O4/Au) nanocomposites was significantly enhanced in drug-resistant breast cancer cells. Moreover, PSiNPs@(Fe3O4/Au) nanocomposites as carriers showed a high loading and NIR light-triggered release of anticancer drug. Based on the synergistic effect of magnetic field-enhanced cellular uptake and NIR light-triggered intracellular release, the amount of anticancer drug carried by PSiNPs@(Fe3O4/Au) nanocarriers into the nuclei of drug-resistant breast cancer cells sharply increased, accompanied with improved chemo-photothermal therapeutic efficacy. Finally, PSiNPs@(Fe3O4/Au) nanocomposites under the combination conditions of magnetic field attraction and NIR light irradiation also showed improved anticancer drug penetration and accumulation in three-dimensional multicellular spheroids composed of drug-resistant breast cancer cells, leading to better growth inhibition effect. Overall, the fabricated PSiNPs@(Fe3O4/Au) nanocomposites demonstrated great potential for the therapy of multidrug-resistant breast cancer in future.

AB - The development of drug delivery systems based on external stimuli-responsive nanocarriers is important to overcome multidrug resistance of breast cancer cells. Herein, iron oxide/gold (Fe3O4/Au) nanoparticles were first fabricated via a simple hydrothermal reaction, and subsequently loaded into porous silicon nanoparticles (PSiNPs) via electrostatic interactions to construct PSiNPs@(Fe3O4/Au) nanocomposites. As-prepared PSiNPs@(Fe3O4/Au) nanocomposites exhibited excellent super-paramagnetism, photothermal effect, and T2-weight magnetic resonance imaging capability. Particularly, with the help of magnetic field, the cellular uptake of PSiNPs@(Fe3O4/Au) nanocomposites was significantly enhanced in drug-resistant breast cancer cells. Moreover, PSiNPs@(Fe3O4/Au) nanocomposites as carriers showed a high loading and NIR light-triggered release of anticancer drug. Based on the synergistic effect of magnetic field-enhanced cellular uptake and NIR light-triggered intracellular release, the amount of anticancer drug carried by PSiNPs@(Fe3O4/Au) nanocarriers into the nuclei of drug-resistant breast cancer cells sharply increased, accompanied with improved chemo-photothermal therapeutic efficacy. Finally, PSiNPs@(Fe3O4/Au) nanocomposites under the combination conditions of magnetic field attraction and NIR light irradiation also showed improved anticancer drug penetration and accumulation in three-dimensional multicellular spheroids composed of drug-resistant breast cancer cells, leading to better growth inhibition effect. Overall, the fabricated PSiNPs@(Fe3O4/Au) nanocomposites demonstrated great potential for the therapy of multidrug-resistant breast cancer in future.

KW - 317 Pharmacy

KW - 221 Nano-technology

KW - ANTICANCER DRUGS

KW - TARGETED-THERAPY

KW - DELIVERY-SYSTEMS

KW - NANOPARTICLES

KW - DOXORUBICIN

KW - NANOCOMPOSITES

KW - NANOMEDICINES

KW - PLATFORM

U2 - 10.1039/C9TB02340B

DO - 10.1039/C9TB02340B

M3 - Article

VL - 8

SP - 546

EP - 557

JO - Journal of Materials Chemistry. B

JF - Journal of Materials Chemistry. B

SN - 2050-750X

IS - 3

ER -