Neonatal Seizures: Is there a relationship between ictal electro-clinical features and etiology? – A critical appraisal based on a systematic literature review

Magda L. Nunes, Elissa G. Yozawitz, Sameer Zuberi, Eli M. Mizrahi, Maria Roberta Cilio, Solomon L. Moshé, Perrine Plouin, Sampsa Vanhatalo, Ronit M Pressler

Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review


Abstract The aim of this study was to evaluate whether specific etiologies of neonatal seizures have distinct ictal electro- clinical features. A systematic review of English articles using the PubMed database since 2004 (last update 9/26/16). Search terms included text words and MeSH terms related to neonatal seizures. Eligible articles included reports of neonates with seizures with a full description of seizure semiology and electroclinical findings. Independent extraction of data was performed by two authors using predefined data fields, including study quality indicators. Data was collected for every individual patient described in the articles. The dataset was analyzed with the Fisher?s exact test. The initial search led to 8507 titles; using filters, 2910 titles and abstracts were identified, with 177 full texts selected to be read. Fifty seven studies were included in the analysis with 151 neonates (37.7 male and 62.9% term). Genetic etiologies (51%) and sequential seizures (41.1%) predominated in this sample and hypoxic ischemic encephalopathy (HIE) accounted for only 4%. The low prevalence of HIE observed was probably due to a publication bias. A significant association was found between etiology and seizure type: hemorrhage with autonomic seizures (p=0.003), CNS infection and stroke with clonic seizures (p=0.042, p
TidskriftEpilepsia Open
Sidor (från-till)10-29
Antal sidor20
StatusPublicerad - 2019
MoE-publikationstypA1 Tidskriftsartikel-refererad


  • 3112 Neurovetenskaper
  • 3124 Neurologi och psykiatri

Citera det här