TY - JOUR
T1 - Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis
AU - Gronblad, M.
AU - Konttinen, Y. T.
AU - Korkala, O.
AU - Liesi, P.
AU - Hukkanen, M.
AU - Polak, J. M.
N1 - LR: 20041117; JID: 7501984; 0 (Enkephalins); 0 (Neuropeptides); 58569-55-4 (Enkephalin, Methionine); 58822-25-6 (Enkephalin, Leucine); 83652-28-2 (Calcitonin Gene-Related Peptide); 9007-12-9 (Calcitonin); ppublish
PY - 1988
Y1 - 1988
N2 - The presence of neural elements in synovial tissue proper has earlier been suggested on the basis of nonspecific silver impregnation techniques and is now confirmed in a study based on specific demonstration of cytoskeletal neurofilaments and various neuropeptides. With both the neurofilament and neuropeptide antisera, nerves were seen predominantly in a perivascular location, there being fewer nerves freely in the stromal tissue. In the synovium of patients with rheumatoid arthritis (RA), free stromal nerves stained with neurofilament antiserum often lacked neuropeptide immunoreactivity, while this was not the case in normal synovium or synovial samples from patients with osteoarthritis (OA). Furthermore, the intensity of staining of neurotransmitter peptides was weaker in RA than in OA or normal synovial tissue. It is suggested that neurogenic inflammation may play a role in RA and that neuropeptide nerves possibly release their mediators in RA.
AB - The presence of neural elements in synovial tissue proper has earlier been suggested on the basis of nonspecific silver impregnation techniques and is now confirmed in a study based on specific demonstration of cytoskeletal neurofilaments and various neuropeptides. With both the neurofilament and neuropeptide antisera, nerves were seen predominantly in a perivascular location, there being fewer nerves freely in the stromal tissue. In the synovium of patients with rheumatoid arthritis (RA), free stromal nerves stained with neurofilament antiserum often lacked neuropeptide immunoreactivity, while this was not the case in normal synovium or synovial samples from patients with osteoarthritis (OA). Furthermore, the intensity of staining of neurotransmitter peptides was weaker in RA than in OA or normal synovial tissue. It is suggested that neurogenic inflammation may play a role in RA and that neuropeptide nerves possibly release their mediators in RA.
KW - Arthritis, Rheumatoid/immunology
KW - Calcitonin/analysis
KW - Calcitonin Gene-Related Peptide
KW - Enkephalin, Leucine/analysis
KW - Enkephalin, Methionine/analysis
KW - Enkephalins/analysis
KW - Humans
KW - Immunoenzyme Techniques
KW - Intermediate Filaments/immunology
KW - Neuropeptides/analysis
KW - Osteoarthritis/immunology
KW - Synovial Membrane/immunology
M3 - Article
SN - 0315-162X
VL - 15
SP - 1807
EP - 1810
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -