New reference limits for cardiac troponin T and N-terminal b-type natriuretic propeptide in elders

Elisa Heikkilä, Taina Katajamäki, Marika Salminen, Kerttu Irjala, Anna Viljanen, Marja-Kaisa Koivula, Kari Pulkki, Raimo Isoaho, Sirkka Liisa Kivelä, Matti Viitanen, Minna Löppönen, Tero Vahlberg, Laura Viikari

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Sammanfattning

Background and aims: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute myocardial infarctions (AMIs) was studied using these reference limits in an older population with and without previous heart diseases. Materials and methods: A population-based study with a ten-year follow-up. The reference population was formed by 763 individuals aged over 64 years, with no diagnoses of heart or kidney diseases. Results: There was a significant increase in cTnT and proBNP concentrations with age. The 99 % reference limits for cTnT were 25 ng/L, 28 ng/l, 38 ng/l, and 71 ng/l for men in five-year-intervals starting from 64 to 69 years to 80 years and older, and 18 ng/L, 22 ng/l, 26 ng/l, and 52 ng/L for women, respectively. The 97.5 % reference limits for proBNP were 272 ng/L, 287 ng/l, 373 ng/l and 686 ng/L for men, and 341 ng/L, 377 ng/l, 471 ng/l, and 794 ng/L for women, respectively. Elevated proBNP was statistically significantly associated with future AMIs in subjects with and without a previous heart disease. Conclusions: Age-specific reference limits for cTnT and proBNP are needed to better evaluate cardiac symptoms.

Originalspråkengelska
Artikelnummer117844
TidskriftClinica Chimica Acta
Volym556
Antal sidor6
ISSN0009-8981
DOI
StatusPublicerad - 15 mars 2024
MoE-publikationstypA1 Tidskriftsartikel-refererad

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