Non-transferrin-bound iron in haematological patients during chemotherapy and conditioning for autologous stem cell transplantation

Leila Sahlstedt, Leni von Bonsdorff, Freja Ebeling, Jaakko Parkkinen, Eeva Juvonen, Tapani Ruutu

    Forskningsoutput: TidskriftsbidragArtikelVetenskapligPeer review

    Sammanfattning

    Free iron induced hydroxyl radical formation is one possible mechanism for tissue injury during cytotoxic therapy. We studied the appearance of free, non-transferrin-bound iron (NTBI) at baseline and during the 20-d period after the onset of cytotoxic chemotherapy in patients with haematological malignancy undergoing intensive chemotherapy or conditioning for autologous stem cell transplantation (aSCT). NTBI was detected on average for 15.6 d in patients treated with chemotherapy only, and for 6.1 d in patients undergoing aSCT. The recovery of the bone marrow function coincided with the disappearance of NTBI. The type of the conditioning regimen was also associated with the appearance of NTBI. The timing of the presence of NTBI accords with the presence of the most important non-infectious complication of intensive chemotherapy and autologous transplantation, mucosal injury, and free iron is likely to contribute to this and probably other complications of the intensive treatments.
    Originalspråkengelska
    TidskriftEuropean Journal of Haematology
    Volym83
    Nummer5
    Sidor (från-till)455-459
    Antal sidor5
    ISSN0902-4441
    DOI
    StatusPublicerad - 2009
    MoE-publikationstypA1 Tidskriftsartikel-refererad

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