TY - JOUR
T1 - Outcome and complications in postcardiotomy cardiogenic shock treated with extracorporeal life support - a systematic review and meta-analysis
AU - Kienlein, Romana Maria
AU - Trauzeddel, Ralf Felix
AU - Akbari, Nilufar
AU - Avalli, Leonello
AU - Biancari, Fausto
AU - Dini, Carlotta Sorini
AU - Guenther, Sabina
AU - Hagl, Christian
AU - Heringlake, Matthias
AU - Kruppa, Jochen
AU - Mäkikallio, Timo
AU - Martins, Raphael
AU - de Chambrun, Marc Pineton
AU - Rastan, Ardawan Julian
AU - Rubino, Antonio
AU - van den Brink, Floris
AU - Nordine, Michael
AU - Treskatsch, Sascha
N1 - Publisher Copyright:
© 2025. The Author(s).
PY - 2025/1/17
Y1 - 2025/1/17
N2 - BACKGROUND: Postcardiotomy cardiogenic shock (PCCS) in cardiac surgery is associated with a high rate of morbidity and mortality. Beside other therapeutic measures (e.g. intraaortic balloon pump (IABP)), extracorporeal life support is being increasingly used in this particular form of shock. Objectives of this meta-analysis were to determine mortality and complications of extracorporeal life support treatment (ECLS) in cardiac surgery patients, and if outcomes were influenced by a preexisting cardiovascular risk profile. METHODS: MEDLINE and EMBASE were searched for studies in English, published between January 1st 2000 and January 16th 2023, reporting mortality and morbidity in patients aged ≥ 18 treated with ECLS for PCCS. Supplementary data were requested from the respective corresponding authors. Outcomes were weaning from extracorporeal life support, hospital survival and complications. RESULTS: Two thousand, seven hundred seventy-four papers were screened, of which 132 full text articles were assessed for suitability. 70 remaining studies were included for further evaluation and data analysis. Five studies could be included in the final analysis since the corresponding authors provided additional necessary information. Successful weaning from extracorporeal life support was accomplished in 52.8% (30.8%-57.4%) and 31.1% were discharged alive (mortality of 25.0 - 56.2% after weaning). 95.1% of all treated patients suffered from at least one complication. Diabetes mellitus and obesity seem to be independent risk factors for poor outcome. CONCLUSIONS: Extracorporeal life support for PCCS is associated with a substantial mortality and complication rate. Diabetes mellitus and obesity seem to be independent risk factors. Therefore, until future work has elucidated which patients benefit at all, the risks of ECLS-treatment must be critically weighed up against a possible benefit.
AB - BACKGROUND: Postcardiotomy cardiogenic shock (PCCS) in cardiac surgery is associated with a high rate of morbidity and mortality. Beside other therapeutic measures (e.g. intraaortic balloon pump (IABP)), extracorporeal life support is being increasingly used in this particular form of shock. Objectives of this meta-analysis were to determine mortality and complications of extracorporeal life support treatment (ECLS) in cardiac surgery patients, and if outcomes were influenced by a preexisting cardiovascular risk profile. METHODS: MEDLINE and EMBASE were searched for studies in English, published between January 1st 2000 and January 16th 2023, reporting mortality and morbidity in patients aged ≥ 18 treated with ECLS for PCCS. Supplementary data were requested from the respective corresponding authors. Outcomes were weaning from extracorporeal life support, hospital survival and complications. RESULTS: Two thousand, seven hundred seventy-four papers were screened, of which 132 full text articles were assessed for suitability. 70 remaining studies were included for further evaluation and data analysis. Five studies could be included in the final analysis since the corresponding authors provided additional necessary information. Successful weaning from extracorporeal life support was accomplished in 52.8% (30.8%-57.4%) and 31.1% were discharged alive (mortality of 25.0 - 56.2% after weaning). 95.1% of all treated patients suffered from at least one complication. Diabetes mellitus and obesity seem to be independent risk factors for poor outcome. CONCLUSIONS: Extracorporeal life support for PCCS is associated with a substantial mortality and complication rate. Diabetes mellitus and obesity seem to be independent risk factors. Therefore, until future work has elucidated which patients benefit at all, the risks of ECLS-treatment must be critically weighed up against a possible benefit.
KW - Extracorporeal life support
KW - Meta-analysis
KW - Outcome
KW - Postcardiotomy cardiogenic shock
KW - Veno-arterial extracorporeal membrane oxygenation
KW - 3126 Surgery, anesthesiology, intensive care, radiology
U2 - 10.1186/s12871-025-02898-2
DO - 10.1186/s12871-025-02898-2
M3 - Article
C2 - 39825250
AN - SCOPUS:85216204833
SN - 1471-2253
VL - 25
JO - BMC Anesthesiology
JF - BMC Anesthesiology
IS - 1
M1 - 29
ER -