Oxidative stress - Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae

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Sammanfattning

Spontaneous preterm birth (PTB) is one of the major complications of pregnancy and the main cause of neonatal mortality and morbidity. Despite the efforts devoted to the understanding of this obstetrical syndrome and improved medical care, there has been a tendency for the PTB rate to increase in the last decades globally. The costs of the screening for spontaneous PTB, its management, and treatment of the sequelae represent a major burden to the health service economy of high-income countries. In this scenario, it has been widely acknowledged that oxidative stress (OS) plays an important role in the pathogenicity of human disease in wide range of areas of medicine. There is an emerging evidence that an imbalance between pro-and-antioxidants may be associated with spontaneous PTB. However, there are still many controversies on the mechanisms by which OS are involved in the pathogenesis of prematurity. Moreover, the crucial question whether the OS is the cause or consequence of the disease is yet to be answered.

The purpose of this article is to briefly summarize the current knowledge and controversies on oxidative stress-related spontaneous PTB and to give a critical approach on future perspectives on this topic as a classical example of translational medicine. Placenta-mediated pregnancy adverse outcome associated with OS leading to iatrogenic PTB (e.g. pre-eclampsia, intrauterine growth restriction, gestational diabetes) will not be discussed.

Originalspråkengelska
TidskriftFree Radical Biology & Medicine
Volym142
Sidor (från-till)52-60
Antal sidor9
ISSN0891-5849
DOI
StatusPublicerad - okt 2019
MoE-publikationstypA2 Granska artikel i en vetenskaplig tidskrift

Vetenskapsgrenar

  • 1182 Biokemi, cell- och molekylärbiologi
  • 3111 Biomedicinska vetenskaper
  • 3123 Kvinno- och barnsjukdomar

Citera det här

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title = "Oxidative stress - Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae",
abstract = "Spontaneous preterm birth (PTB) is one of the major complications of pregnancy and the main cause of neonatal mortality and morbidity. Despite the efforts devoted to the understanding of this obstetrical syndrome and improved medical care, there has been a tendency for the PTB rate to increase in the last decades globally. The costs of the screening for spontaneous PTB, its management, and treatment of the sequelae represent a major burden to the health service economy of high-income countries. In this scenario, it has been widely acknowledged that oxidative stress (OS) plays an important role in the pathogenicity of human disease in wide range of areas of medicine. There is an emerging evidence that an imbalance between pro-and-antioxidants may be associated with spontaneous PTB. However, there are still many controversies on the mechanisms by which OS are involved in the pathogenesis of prematurity. Moreover, the crucial question whether the OS is the cause or consequence of the disease is yet to be answered.The purpose of this article is to briefly summarize the current knowledge and controversies on oxidative stress-related spontaneous PTB and to give a critical approach on future perspectives on this topic as a classical example of translational medicine. Placenta-mediated pregnancy adverse outcome associated with OS leading to iatrogenic PTB (e.g. pre-eclampsia, intrauterine growth restriction, gestational diabetes) will not be discussed.",
keywords = "AMNIOTIC-FLUID, ANTIOXIDANT ENZYMES, Amniocentesis, Amniotic fluid, BIRTH, Biomarkers, FETAL, IN-VIVO, Intrauterine inflammation, MEMBRANES, Microbial invasion of the amniotic cavity, N-ACETYLCYSTEINE, NEONATAL BRAIN, Oxidative stress, PRELABOR RUPTURE, PREMATURE RUPTURE, Placenta, Prematurity, 1182 Biochemistry, cell and molecular biology, 3111 Biomedicine, 3123 Gynaecology and paediatrics",
author = "Vedran Stefanovic and Sture Andersson and Maximo Vento",
year = "2019",
month = "10",
doi = "10.1016/j.freeradbiomed.2019.06.008",
language = "English",
volume = "142",
pages = "52--60",
journal = "Free Radical Biology & Medicine",
issn = "0891-5849",
publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",

}

TY - JOUR

T1 - Oxidative stress - Related spontaneous preterm delivery challenges in causality determination, prevention and novel strategies in reduction of the sequelae

AU - Stefanovic, Vedran

AU - Andersson, Sture

AU - Vento, Maximo

PY - 2019/10

Y1 - 2019/10

N2 - Spontaneous preterm birth (PTB) is one of the major complications of pregnancy and the main cause of neonatal mortality and morbidity. Despite the efforts devoted to the understanding of this obstetrical syndrome and improved medical care, there has been a tendency for the PTB rate to increase in the last decades globally. The costs of the screening for spontaneous PTB, its management, and treatment of the sequelae represent a major burden to the health service economy of high-income countries. In this scenario, it has been widely acknowledged that oxidative stress (OS) plays an important role in the pathogenicity of human disease in wide range of areas of medicine. There is an emerging evidence that an imbalance between pro-and-antioxidants may be associated with spontaneous PTB. However, there are still many controversies on the mechanisms by which OS are involved in the pathogenesis of prematurity. Moreover, the crucial question whether the OS is the cause or consequence of the disease is yet to be answered.The purpose of this article is to briefly summarize the current knowledge and controversies on oxidative stress-related spontaneous PTB and to give a critical approach on future perspectives on this topic as a classical example of translational medicine. Placenta-mediated pregnancy adverse outcome associated with OS leading to iatrogenic PTB (e.g. pre-eclampsia, intrauterine growth restriction, gestational diabetes) will not be discussed.

AB - Spontaneous preterm birth (PTB) is one of the major complications of pregnancy and the main cause of neonatal mortality and morbidity. Despite the efforts devoted to the understanding of this obstetrical syndrome and improved medical care, there has been a tendency for the PTB rate to increase in the last decades globally. The costs of the screening for spontaneous PTB, its management, and treatment of the sequelae represent a major burden to the health service economy of high-income countries. In this scenario, it has been widely acknowledged that oxidative stress (OS) plays an important role in the pathogenicity of human disease in wide range of areas of medicine. There is an emerging evidence that an imbalance between pro-and-antioxidants may be associated with spontaneous PTB. However, there are still many controversies on the mechanisms by which OS are involved in the pathogenesis of prematurity. Moreover, the crucial question whether the OS is the cause or consequence of the disease is yet to be answered.The purpose of this article is to briefly summarize the current knowledge and controversies on oxidative stress-related spontaneous PTB and to give a critical approach on future perspectives on this topic as a classical example of translational medicine. Placenta-mediated pregnancy adverse outcome associated with OS leading to iatrogenic PTB (e.g. pre-eclampsia, intrauterine growth restriction, gestational diabetes) will not be discussed.

KW - AMNIOTIC-FLUID

KW - ANTIOXIDANT ENZYMES

KW - Amniocentesis

KW - Amniotic fluid

KW - BIRTH

KW - Biomarkers

KW - FETAL

KW - IN-VIVO

KW - Intrauterine inflammation

KW - MEMBRANES

KW - Microbial invasion of the amniotic cavity

KW - N-ACETYLCYSTEINE

KW - NEONATAL BRAIN

KW - Oxidative stress

KW - PRELABOR RUPTURE

KW - PREMATURE RUPTURE

KW - Placenta

KW - Prematurity

KW - 1182 Biochemistry, cell and molecular biology

KW - 3111 Biomedicine

KW - 3123 Gynaecology and paediatrics

U2 - 10.1016/j.freeradbiomed.2019.06.008

DO - 10.1016/j.freeradbiomed.2019.06.008

M3 - Review Article

VL - 142

SP - 52

EP - 60

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

SN - 0891-5849

ER -