Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

Mahesh Tambe; Ella Karjalainen; Markus Vähä-Koskela; Daria Bulanova; Bjorn T. Gjertsen; Mika Kontro; Kimmo Porkka; Caroline A. Heckman; Krister Wennerberg

doi:10.1038/s41375-020-0972-0

Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

Mahesh Tambe, Ella Karjalainen, Markus Vähä-Koskela, Daria Bulanova, Bjorn T. Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A. Heckman, Krister Wennerberg

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Tidskrift	Leukemia
Volym	34
Nummer	12
Sidor (från-till)	3186-3196
Antal sidor	11
ISSN	0887-6924
DOI	https://doi.org/10.1038/s41375-020-0972-0
Status	Publicerad - dec. 2020
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Vetenskapsgrenar

3122 Cancersjukdomar

Åtkomst av dokument

10.1038/s41375-020-0972-0

Citera det här

@article{6bd282f8d9714ae39d551a4257cb7293,

title = "Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition",

keywords = "ACUTE MYELOGENOUS LEUKEMIA, KINASE, LY3009120, MEK, INDUCTION, STRATEGY, PATHWAY, MODELS, MCL-1, BRAF, 3122 Cancers",

author = "Mahesh Tambe and Ella Karjalainen and Markus V{\"a}h{\"a}-Koskela and Daria Bulanova and Gjertsen, {Bjorn T.} and Mika Kontro and Kimmo Porkka and Heckman, {Caroline A.} and Krister Wennerberg",

year = "2020",

month = dec,

doi = "10.1038/s41375-020-0972-0",

language = "English",

volume = "34",

pages = "3186--3196",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition

AU - Tambe, Mahesh

AU - Karjalainen, Ella

AU - Vähä-Koskela, Markus

AU - Bulanova, Daria

AU - Gjertsen, Bjorn T.

AU - Kontro, Mika

AU - Porkka, Kimmo

AU - Heckman, Caroline A.

AU - Wennerberg, Krister

PY - 2020/12

Y1 - 2020/12

KW - ACUTE MYELOGENOUS LEUKEMIA

KW - KINASE

KW - LY3009120

KW - MEK

KW - INDUCTION

KW - STRATEGY

KW - PATHWAY

KW - MODELS

KW - MCL-1

KW - BRAF

KW - 3122 Cancers

U2 - 10.1038/s41375-020-0972-0

DO - 10.1038/s41375-020-0972-0

M3 - Article

VL - 34

SP - 3186

EP - 3196

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 12

ER -