Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Heidi M. Haikala; Johanna M. Anttila; Elsa Marques; Tiina Raatikainen; Mette Ilander; Henna Hakanen; Hanna Ala-Hongisto; Mariel Savelius; Diego Balboa; Bjoern Von Eyss; Vilja Eskelinen; Pauliina Munne; Anni I. Nieminen; Timo Otonkoski; Julia Schüler; Teemu D. Laajala; Tero Aittokallio; Harri Sihto; Johanna Mattson; Päivi Heikkilä; Marjut Leidenius; Heikki Joensuu; Satu Mustjoki; Panu Kovanen; Martin Eilers; Joel D. Leverson; Juha Klefström

doi:10.1038/s41467-019-08541-2

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Heidi M. Haikala, Johanna M. Anttila, Elsa Marques, Tiina Raatikainen, Mette Ilander, Henna Hakanen, Hanna Ala-Hongisto, Mariel Savelius, Diego Balboa, Bjoern Von Eyss, Vilja Eskelinen, Pauliina Munne, Anni I. Nieminen, Timo Otonkoski, Julia Schüler, Teemu D. Laajala, Tero Aittokallio, Harri Sihto, Johanna Mattson, Päivi HeikkiläMarjut Leidenius, Heikki Joensuu, Satu Mustjoki, Panu Kovanen, Martin Eilers, Joel D. Leverson, Juha Klefström

Forskningsoutput: Tidskriftsbidrag › Artikel › Vetenskaplig › Peer review

Originalspråk	engelska
Artikelnummer	620
Tidskrift	Nature Communications
Volym	10
Antal sidor	17
ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-019-08541-2
Status	Publicerad - 6 feb. 2019
MoE-publikationstyp	A1 Tidskriftsartikel-refererad

Bibliografisk information

Correction: Volume: 10
Article Number: 932
DOI: 10.1038/s41467-019-08956-x
Published: FEB 20 2019
Accession Number: WOS:000459099300001

Vetenskapsgrenar

3111 Biomedicinska vetenskaper
3122 Cancersjukdomar

Åtkomst av dokument

10.1038/s41467-019-08541-2

s41467-019-08541-2Slutlig publicerad version, 4,03 MBLicens: CC BY
CorrectionSlutlig publicerad version, 441 KB

Citera det här

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., ... Klefström, J. (2019). Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. Nature Communications, 10, Artikel 620. https://doi.org/10.1038/s41467-019-08541-2

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title = "Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy",

keywords = "IN-VIVO EFFICACY, C-MYC, GENE-EXPRESSION, BREAST-CANCER, METFORMIN, ACTIVATION, MECHANISMS, ABT-737, BCL-2, BIM, 3111 Biomedicine, 3122 Cancers",

author = "Haikala, {Heidi M.} and Anttila, {Johanna M.} and Elsa Marques and Tiina Raatikainen and Mette Ilander and Henna Hakanen and Hanna Ala-Hongisto and Mariel Savelius and Diego Balboa and {Von Eyss}, Bjoern and Vilja Eskelinen and Pauliina Munne and Nieminen, {Anni I.} and Timo Otonkoski and Julia Sch{\"u}ler and Laajala, {Teemu D.} and Tero Aittokallio and Harri Sihto and Johanna Mattson and P{\"a}ivi Heikkil{\"a} and Marjut Leidenius and Heikki Joensuu and Satu Mustjoki and Panu Kovanen and Martin Eilers and Leverson, {Joel D.} and Juha Klefstr{\"o}m",

note = "Correction: Volume: 10 Article Number: 932 DOI: 10.1038/s41467-019-08956-x Published: FEB 20 2019 Accession Number: WOS:000459099300001 ",

year = "2019",

month = feb,

day = "6",

doi = "10.1038/s41467-019-08541-2",

language = "English",

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Haikala, HM, Anttila, JM, Marques, E, Raatikainen, T, Ilander, M, Hakanen, H, Ala-Hongisto, H, Savelius, M , Balboa, D, Von Eyss, B, Eskelinen, V, Munne, P , Nieminen, AI , Otonkoski, T, Schüler, J, Laajala, TD, Aittokallio, T , Sihto, H , Mattson, J , Heikkilä, P , Leidenius, M , Joensuu, H , Mustjoki, S , Kovanen, P, Eilers, M, Leverson, JD & Klefström, J 2019, 'Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy', Nature Communications, vol. 10, 620. https://doi.org/10.1038/s41467-019-08541-2

TY - JOUR

T1 - Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

AU - Haikala, Heidi M.

AU - Anttila, Johanna M.

AU - Marques, Elsa

AU - Raatikainen, Tiina

AU - Ilander, Mette

AU - Hakanen, Henna

AU - Ala-Hongisto, Hanna

AU - Savelius, Mariel

AU - Balboa, Diego

AU - Von Eyss, Bjoern

AU - Eskelinen, Vilja

AU - Munne, Pauliina

AU - Nieminen, Anni I.

AU - Otonkoski, Timo

AU - Schüler, Julia

AU - Laajala, Teemu D.

AU - Aittokallio, Tero

AU - Sihto, Harri

AU - Mattson, Johanna

AU - Heikkilä, Päivi

AU - Leidenius, Marjut

AU - Joensuu, Heikki

AU - Mustjoki, Satu

AU - Kovanen, Panu

AU - Eilers, Martin

AU - Leverson, Joel D.

AU - Klefström, Juha

N1 - Correction: Volume: 10 Article Number: 932 DOI: 10.1038/s41467-019-08956-x Published: FEB 20 2019 Accession Number: WOS:000459099300001

PY - 2019/2/6

Y1 - 2019/2/6

KW - IN-VIVO EFFICACY

KW - C-MYC

KW - GENE-EXPRESSION

KW - BREAST-CANCER

KW - METFORMIN

KW - ACTIVATION

KW - MECHANISMS

KW - ABT-737

KW - BCL-2

KW - BIM

KW - 3111 Biomedicine

KW - 3122 Cancers

U2 - 10.1038/s41467-019-08541-2

DO - 10.1038/s41467-019-08541-2

M3 - Article

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

M1 - 620

ER -